CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005221
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Vesicle-associated membrane protein 1 
Protein Synonyms/Alias
 VAMP-1; Synaptobrevin-1 
Gene Name
 VAMP1 
Gene Synonyms/Alias
 SYB1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
85QFESSAAKLKRKYWWubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
 Involved in the targeting and/or fusion of transport vesicles to their target membrane. 
Sequence Annotation
 DOMAIN 33 93 v-SNARE coiled-coil homology.
 MOD_RES 63 63 Phosphoserine (By similarity).  
Keyword
 Alternative splicing; Cell junction; Coiled coil; Complete proteome; Cytoplasmic vesicle; Membrane; Mitochondrion; Mitochondrion outer membrane; Phosphoprotein; Reference proteome; Synapse; Synaptosome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 118 AA 
Protein Sequence
MSAPAQPPAE GTEGTAPGGG PPGPPPNMTS NRRLQQTQAQ VEEVVDIIRV NVDKVLERDQ 60
KLSELDDRAD ALQAGASQFE SSAAKLKRKY WWKNCKMMIM LGAICAIIVV VIVRRD 116 
Gene Ontology
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0030666; C:endocytic vesicle membrane; TAS:Reactome.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
 GO:0043005; C:neuron projection; IEA:UniProtKB-SubCell.
 GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0007269; P:neurotransmitter secretion; TAS:Reactome.
 GO:0016192; P:vesicle-mediated transport; IEA:InterPro. 
Interpro
 IPR001388; Synaptobrevin.
 IPR016444; Synaptobrevin_met/fun. 
Pfam
 PF00957; Synaptobrevin 
SMART
  
PROSITE
 PS00417; SYNAPTOBREVIN
 PS50892; V_SNARE 
PRINTS
 PR00219; SYNAPTOBREVN.