CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044036
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Poly [ADP-ribose] polymerase 14 
Protein Synonyms/Alias
  
Gene Name
 PARP14 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
119LIEFFDRKVLDTIMAubiquitination[1]
128LDTIMATKLDFNKMPubiquitination[1]
152LGTALYGKEKPLIKLubiquitination[1]
158GKEKPLIKLPAPFEEubiquitination[1]
173SLDLPLWKFLQKKNHubiquitination[1]
178LWKFLQKKNHLIEEIubiquitination[1]
222NEGRPRIKTWQADTSubiquitination[1, 2, 3, 4]
240SSIRSKYKVNPIKVDmethylation[5]
240SSIRSKYKVNPIKVDubiquitination[1]
245KYKVNPIKVDPTMWDubiquitination[1]
255PTMWDTIKNDVKDDRubiquitination[1]
300LIESTTQKIKREEQSubiquitination[1, 4]
302ESTTQKIKREEQSLKubiquitination[1, 6]
311EEQSLKEKMIISPGRubiquitination[1]
352VTQHLCLKGPSADVYubiquitination[1]
360GPSADVYKAKCEIQEubiquitination[1]
368AKCEIQEKVYTMAQKubiquitination[1]
440MLSALNYKRIEVENKubiquitination[2]
454KEVLHGKKWKGLTHNubiquitination[1]
456VLHGKKWKGLTHNLLubiquitination[1]
465LTHNLLKKQNSSPNTubiquitination[1]
511NFVEQNMKIERLVEVubiquitination[1]
519IERLVEVKPSLVIDYubiquitination[1, 4]
528SLVIDYLKTEKKLFWubiquitination[1, 4]
552VSFNPENKQKGILLTubiquitination[3]
554FNPENKQKGILLTGSubiquitination[1]
562GILLTGSKTEVLKAVubiquitination[1]
567GSKTEVLKAVDIVKQubiquitination[1]
573LKAVDIVKQVWDSVCubiquitination[1]
582VWDSVCVKSVHTDKPubiquitination[1]
588VKSVHTDKPGAKQFFubiquitination[1]
592HTDKPGAKQFFQDKAubiquitination[1]
598AKQFFQDKARFYQSEubiquitination[1]
623LQENEVMKEGGSPAGubiquitination[1]
632GGSPAGQKCFSRTVLubiquitination[1, 4]
669NASNEDLKHYGGLAAubiquitination[1, 4, 6]
680GLAAALSKAAGPELQubiquitination[1]
695ADCDQIVKREGRLLPubiquitination[1, 3, 4]
709PGNATISKAGKLPYHubiquitination[1, 4]
712ATISKAGKLPYHHVIubiquitination[1]
751LSLCLAEKYKYRSIAubiquitination[1]
783ETIVSAIKENFQFKKubiquitination[1]
796KKDGHCLKEIYLVDVubiquitination[1]
816EAFAEAVKTVFKATLubiquitination[1]
820EAVKTVFKATLPDTAubiquitination[1]
846PGKTSWEKGSLVSPGubiquitination[1, 3]
861GLQMLLVKEGVQNAKubiquitination[1, 3]
868KEGVQNAKTDVVVNSubiquitination[1]
889LSRGPLSKSLLEKAGubiquitination[1, 3, 4]
1039NGNLVSDKIPKAKDTubiquitination[1]
1044SDKIPKAKDTQGFYGubiquitination[1, 3, 6]
1101NLKAGVSKAILECAGubiquitination[1, 3]
1123SQQAQQRKNDYIITGubiquitination[1, 4]
1137GGGFLRCKNIIHVIGubiquitination[1]
1149VIGGNDVKSSVSSVLubiquitination[1]
1162VLQECEKKNYSSICLubiquitination[1]
1198AIEDFVQKGSAQSVKubiquitination[6]
1241SQQSVMSKLASFLGFubiquitination[1]
1250ASFLGFSKQSPQKKNubiquitination[1, 4]
1306TSEDECIKDFDEKEYubiquitination[1]
1322ELNELQKKLNINISLubiquitination[1]
1337DHKRPLIKVLGISRDubiquitination[1]
1357DEIEAMIKRVRLAKEubiquitination[1, 3]
1396FNKMTNLKLEDARREubiquitination[1]
1411KKKTVDVKINHRHYTubiquitination[1]
1430TYTATDTKGHSLSVQubiquitination[1, 3]
1443VQRLTKSKVDIPAHWubiquitination[1]
1454PAHWSDMKQQNFCVVubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510]
 [6] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1521 AA 
Protein Sequence
VTDIMLILLV ENISGLSNDD FQVEIIRDFD VAVVTFQKHI DTIRFVDDCT KHHSIKQLQL 60
SPRLLEVTNT IRVENLPPGA DDYSLKLFFE NPYNGGGRVA NVEYFPEESS ALIEFFDRKV 120
LDTIMATKLD FNKMPLSVFP YYASLGTALY GKEKPLIKLP APFEESLDLP LWKFLQKKNH 180
LIEEINDEMR RCHCELTWSQ LSGKVTIRPA ATLVNEGRPR IKTWQADTST TLSSIRSKYK 240
VNPIKVDPTM WDTIKNDVKD DRILIEFDTL KEMVILAGKS EDVQSIEVQV RELIESTTQK 300
IKREEQSLKE KMIISPGRYF LLCHSSLLDH LLTECPEIEI CYDRVTQHLC LKGPSADVYK 360
AKCEIQEKVY TMAQKNIQVS PEIFQFLQQV NWKEFSKCLF IAQKILALYE LEGTTVLLTS 420
CSSEALLEAE KQMLSALNYK RIEVENKEVL HGKKWKGLTH NLLKKQNSSP NTVIINELTS 480
ETTAEVIITG CVKEVNETYK LLFNFVEQNM KIERLVEVKP SLVIDYLKTE KKLFWPKIKK 540
VNVQVSFNPE NKQKGILLTG SKTEVLKAVD IVKQVWDSVC VKSVHTDKPG AKQFFQDKAR 600
FYQSEIKRLF GCYIELQENE VMKEGGSPAG QKCFSRTVLA PGVVLIVQQG DLARLPVDVV 660
VNASNEDLKH YGGLAAALSK AAGPELQADC DQIVKREGRL LPGNATISKA GKLPYHHVIH 720
AVGPRWSGYE APRCVYLLRR AVQLSLCLAE KYKYRSIAIP AISSGVFGFP LGRCVETIVS 780
AIKENFQFKK DGHCLKEIYL VDVSEKTVEA FAEAVKTVFK ATLPDTAAPP GLPPAAAGPG 840
KTSWEKGSLV SPGGLQMLLV KEGVQNAKTD VVVNSVPLDL VLSRGPLSKS LLEKAGPELQ 900
EELDTVGQGV AVSMGTVLKT SSWNLDCRYV LHVVAPEWRN GSTSSLKIME DIIRECMEIT 960
ESLSLKSIAF PAIGTGNLGF PKNIFAELII SEVFKFSSKN QLKTLQEVHF LLHPSDHENI 1020
QAFSDEFARR ANGNLVSDKI PKAKDTQGFY GTVSSPDSGV YEMKIGSIIF QVASGDITKE 1080
EADVIVNSTS NSFNLKAGVS KAILECAGQN VERECSQQAQ QRKNDYIITG GGFLRCKNII 1140
HVIGGNDVKS SVSSVLQECE KKNYSSICLP AIGTGNAKQH PDKVAEAIID AIEDFVQKGS 1200
AQSVKKVKVV IFLPQVLDVF YANMKKREGT QLSSQQSVMS KLASFLGFSK QSPQKKNHLV 1260
LEKKTESATF RVCGENVTCV EYAISWLQDL IEKEQCPYTS EDECIKDFDE KEYQELNELQ 1320
KKLNINISLD HKRPLIKVLG ISRDVMQARD EIEAMIKRVR LAKEQESRAD CISEFIEWQY 1380
NDNNTSHCFN KMTNLKLEDA RREKKKTVDV KINHRHYTVN LNTYTATDTK GHSLSVQRLT 1440
KSKVDIPAHW SDMKQQNFCV VELLPSDPEY NTVASKFNQT CSHFRIEKVS LLLECSFWMV 1500
EISSVMVLYK IHFHSLPITF F 1521 
Gene Ontology
  
Interpro
 IPR002589; A1pp.
 IPR004170; WWE-dom. 
Pfam
 PF01661; Macro
 PF02825; WWE 
SMART
 SM00506; A1pp 
PROSITE
 PS51154; MACRO
 PS50918; WWE 
PRINTS