UniProt Accession

 BASP1_HUMAN; P80723; B4DJA8; D3DTD5; O43596; Q5U0S0; Q9BWA5 

Genbank Protein ID

 AF039656; BT019340; BT019341; AK295995; CH471102; CH471102; BC000518 

Genbank Nucleotide ID

 AAC67374.1; AAV38147.1; AAV38148.1; BAG58770.1; EAX08012.1; EAX08013.1; AAH00518.1 

Protein Name

 Brain acid soluble protein 1 

Protein Synonyms/Alias

 22 kDa neuronal tissue-enriched acidic protein; Neuronal axonal membrane protein NAP-22 

Gene Name

 BASP1 

Gene Synonyms/Alias

 NAP22 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
18	GYNVNDEKAKEKDKK	ubiquitination	[1, 2]
24	EKAKEKDKKAEGAAT	ubiquitination	[1]
25	KAKEKDKKAEGAATE	ubiquitination	[2]
38	TEEEGTPKESEPQAA	ubiquitination	[1, 2]
52	AAEPAEAKEGKEKPD	ubiquitination	[1, 2]
55	PAEAKEGKEKPDQDA	ubiquitination	[2]
57	EAKEGKEKPDQDAEG	ubiquitination	[1, 2]
65	PDQDAEGKAEEKEGE	ubiquitination	[2]
79	EKDAAAAKEEAPKAE	ubiquitination	[1, 2]
84	AAKEEAPKAEPEKTE	ubiquitination	[2]
89	APKAEPEKTEGAAEA	ubiquitination	[1, 2]
97	TEGAAEAKAEPPKAP	ubiquitination	[1, 2]
102	EAKAEPPKAPEQEQA	ubiquitination	[2]
121	AAGGEAPKAAEAAAA	ubiquitination	[2]
143	AAGEEPSKEEGEPKK	ubiquitination	[1, 2]
150	KEEGEPKKTEAPAAP	ubiquitination	[2]
163	APAAQETKSDGAPAS	ubiquitination	[1, 2]
173	GAPASDSKPGSSEAA	ubiquitination	[1, 2, 3]
184	SEAAPSSKETPAATE	ubiquitination	[1, 2]
198	EAPSSTPKAQGPAAS	ubiquitination	[1, 2]
210	AASAEEPKPVEAPAA	ubiquitination	[2]
226	SDQTVTVKE******	ubiquitination	[1, 2, 3]

Reference

 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572] 

Functional Description

  

Sequence Annotation

 MOD_RES 31 31 Phosphothreonine.
 MOD_RES 36 36 Phosphothreonine.
 MOD_RES 164 164 Phosphoserine.
 MOD_RES 170 170 Phosphoserine.
 MOD_RES 172 172 Phosphoserine.
 MOD_RES 176 176 Phosphoserine.
 MOD_RES 196 196 Phosphothreonine.
 MOD_RES 205 205 Phosphoserine.
 MOD_RES 219 219 Phosphoserine (By similarity).
 LIPID 2 2 N-myristoyl glycine.  

Keyword

 Alternative splicing; Cell membrane; Cell projection; Complete proteome; Direct protein sequencing; Lipoprotein; Membrane; Myristate; Phosphoprotein; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 227 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0005856; C:cytoskeleton; TAS:ProtInc.
 GO:0030426; C:growth cone; IEA:UniProtKB-SubCell.
 GO:0016607; C:nuclear speck; ISS:UniProtKB.
 GO:0005886; C:plasma membrane; TAS:ProtInc.
 GO:0003714; F:transcription corepressor activity; IMP:UniProtKB.
 GO:0044212; F:transcription regulatory region DNA binding; ISS:UniProtKB.
 GO:0060539; P:diaphragm development; ISS:UniProtKB.
 GO:0072112; P:glomerular visceral epithelial cell differentiation; ISS:UniProtKB.
 GO:0008406; P:gonad development; ISS:UniProtKB.
 GO:0060231; P:mesenchymal to epithelial transition; ISS:UniProtKB.
 GO:0072075; P:metanephric mesenchyme development; ISS:UniProtKB.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:UniProtKB.
 GO:0060421; P:positive regulation of heart growth; ISS:UniProtKB.
 GO:2001076; P:positive regulation of metanephric ureteric bud development; ISS:UniProtKB.
 GO:0007356; P:thorax and anterior abdomen determination; ISS:UniProtKB. 

Interpro

 IPR008408; BASP1. 

Pfam

 PF05466; BASP1 

SMART

  

PROSITE

  

PRINTS