CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005225
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Glucan 1,3-beta-glucosidase I/II 
Protein Synonyms/Alias
 Exo-1,3-beta-glucanase I/II; Soluble cell wall protein 6 
Gene Name
 EXG1 
Gene Synonyms/Alias
 BGL1; SCW6; YLR300W; L8003.3 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
438PQPLTDRKYPNQCGTubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Glucanases possibly play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme hydrolyzes both 1,3-beta- and 1,6- beta-linkages and even has beta-glucosidase activity. It could also function biosynthetically as a transglycosylase. 
Sequence Annotation
 ACT_SITE 232 232 Proton donor (By similarity).
 ACT_SITE 334 334 Nucleophile (By similarity).
 CARBOHYD 165 165 N-linked (GlcNAc...).
 CARBOHYD 325 325 N-linked (GlcNAc...).  
Keyword
 3D-structure; Cell wall; Cell wall biogenesis/degradation; Cleavage on pair of basic residues; Complete proteome; Direct protein sequencing; Glycoprotein; Glycosidase; Hydrolase; Reference proteome; Secreted; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 448 AA 
Protein Sequence
MLSLKTLLCT LLTVSSVLAT PVPARDPSSI QFVHEENKKR YYDYDHGSLG EPIRGVNIGG 60
WLLLEPYITP SLFEAFRTND DNDEGIPVDE YHFCQYLGKD LAKSRLQSHW STFYQEQDFA 120
NIASQGFNLV RIPIGYWAFQ TLDDDPYVSG LQESYLDQAI GWARNNSLKV WVDLHGAAGS 180
QNGFDNSGLR DSYKFLEDSN LAVTTNVLNY ILKKYSAEEY LDTVIGIELI NEPLGPVLDM 240
DKMKNDYLAP AYEYLRNNIK SDQVIIIHDA FQPYNYWDDF MTENDGYWGV TIDHHHYQVF 300
ASDQLERSID EHIKVACEWG TGVLNESHWT VCGEFAAALT DCTKWLNSVG FGARYDGSWV 360
NGDQTSSYIG SCANNDDIAY WSDERKENTR RYVEAQLDAF EMRGGWIIWC YKTESSLEWD 420
AQRLMFNGLF PQPLTDRKYP NQCGTISN 448 
Gene Ontology
 GO:0005576; C:extracellular region; IDA:SGD.
 GO:0009277; C:fungal-type cell wall; IDA:SGD.
 GO:0004338; F:glucan exo-1,3-beta-glucosidase activity; ISS:SGD.
 GO:0006073; P:cellular glucan metabolic process; IGI:SGD.
 GO:0031505; P:fungal-type cell wall organization; ISS:SGD. 
Interpro
 IPR001547; Glyco_hydro_5.
 IPR018087; Glyco_hydro_5_CS.
 IPR013781; Glyco_hydro_catalytic_dom.
 IPR017853; Glycoside_hydrolase_SF. 
Pfam
 PF00150; Cellulase 
SMART
  
PROSITE
 PS00659; GLYCOSYL_HYDROL_F5 
PRINTS