CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037099
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 
Protein Synonyms/Alias
  
Gene Name
 ARAP1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
626RLGRLPYKAGLSLQRubiquitination[1, 2]
773DARSVHLKEGEQHVDubiquitination[2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; GTPase activation; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1194 AA 
Protein Sequence
MTKKEEPPPS RVPRAVRVAS LLSEGEELSG DDQGDEEEDD HAYEGVPNGG WHTSSLSLSL 60
PSTIAAPHPM DGPPGGSTPV TPVIKAGWLD KNPPQGSYIY QKRWVRLDTD HLRYFDSNKD 120
AYSKRFISVA CISHVAAIGD QKFEVITNNR TFAFRAESDV ERKEWMQALQ QAMAEQRARA 180
RLSSAYLLGV PGSEQPDRAG SLELRGFKNK LYVAVVGDKV QLYKNLEEYH LGIGITFIDM 240
SVGNVKEVDR RSFDLTTPYR IFSFSADSEL EKEQWLEAMQ GAIAEALSTS EVAERIWAAA 300
PNRFCADCGA PQPDWASINL CVVICKRCAG EHRGLGAGVS KVRSLKMDRK VWTETLIELF 360
LQLGNGAGNR FWAANVPPSE ALQPSSSPST RRCHLEAKYR EGKYRRYHPL FGNQEELDKA 420
LCAAVTTTDL AETQALLGCG AGINCFSGDP EAPTPLALAE QAGQTLQMEF LRNNRTTEVP 480
RLDSMKPLEK HYSVVLPTVS HSGFLYKTAS AGKLLQDRRA REEFSRRWCV LGDGVLSYFE 540
NERAVTPNGE IRASEIVCLA VPPPDTHGFE HTFEVYTEGE RLYLFGLESA EQAHEWVKCI 600
AKAFVPPLAE DLLARDFERL GRLPYKAGLS LQRAQEGWFS LSGSELRAVF PEGPCEEPLQ 660
LRKLQELSIQ GDSENQVLVL VERRRTLYIQ GERRLDFMGW LGAIQKAAAS MGDTLSEQQL 720
GDSDIPVIVY RCVDYITQCG LTSEGIYRKC GQTSKTQRLL ESLRQDARSV HLKEGEQHVD 780
DVSSALKRFL RDLPDGLFTR AQRLTWLEAS EIEDEEEKVS RYRELLVRLP PVNRATVKAL 840
ISHLYCVQCF SDTNQMNVHN LAIVFGPTLF QTDGQDYKAG RVVEDLINHY VVVFSVDEEE 900
LRKQREEITA IVKMRVAGTA SGTQHAGDFI CTVYLEEKKA ETEQHIKVPA SMTAEELTLE 960
ILDRRNVGIR EKDYWTCFEV NEREEAERPL HFAEKVLPIL HGLGTDSHLV VKKHQAMEAM 1020
LLYLASRVGD TKHGMMKFRE DRSLLGLGLP SGGFHDRYFI LNSSCLRLYK EVRSHRPEKE 1080
WPIKSLKVYL GVKKKLRPPT CWGFTVVHET EKHEKQQWYL CCDTQMELRE WFATFLFVQH 1140
DGLVWPSEPS RVSRAVPEVR LGSVSLIPLR GSENEMRRSV AAFTADPLSL LRNV 1194 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0008060; F:ARF GTPase activator activity; IEA:InterPro.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0043547; P:positive regulation of GTPase activity; IEA:GOC.
 GO:0032312; P:regulation of ARF GTPase activity; IEA:InterPro.
 GO:0007165; P:signal transduction; IEA:InterPro. 
Interpro
 IPR001164; ArfGAP.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology.
 IPR000159; Ras-assoc.
 IPR008936; Rho_GTPase_activation_prot.
 IPR000198; RhoGAP_dom. 
Pfam
 PF01412; ArfGap
 PF00169; PH
 PF00788; RA
 PF00620; RhoGAP 
SMART
 SM00105; ArfGap
 SM00233; PH
 SM00324; RhoGAP 
PROSITE
 PS50115; ARFGAP
 PS50003; PH_DOMAIN
 PS50200; RA
 PS50238; RHOGAP 
PRINTS
 PR00405; REVINTRACTNG.