CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008086
UniProt Accession
Genbank Protein ID
 U08141 
Genbank Nucleotide ID
Protein Name
 Sodium/calcium exchanger 2 
Protein Synonyms/Alias
 Na(+)/Ca(2+)-exchange protein 2 
Gene Name
 Slc8a2 
Gene Synonyms/Alias
 Ncx2 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
111EKEITITKANGETSVubiquitination[1]
594TMKTLQVKIVDDEEYubiquitination[1]
634NQGDGDRKLTAEEEEubiquitination[1]
675DFKNTVDKLIKKTNLubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores. 
Sequence Annotation
 REPEAT 135 175 Alpha-1.
 DOMAIN 384 483 Calx-beta 1.
 DOMAIN 512 612 Calx-beta 2.
 REPEAT 790 826 Alpha-2.
 REGION 248 267 Calmodulin-binding (By similarity).
 CARBOHYD 34 34 N-linked (GlcNAc...) (Potential).
 CARBOHYD 817 817 N-linked (GlcNAc...) (Potential).  
Keyword
 Antiport; Calcium; Calcium transport; Calmodulin-binding; Complete proteome; Glycoprotein; Ion transport; Membrane; Reference proteome; Repeat; Signal; Sodium; Sodium transport; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 921 AA 
Protein Sequence
MAPLALVGVA LLLGAPHCLG EATPTPSLPP PPANDSDASP GGCQGSYRCQ PGVLLPVWEP 60
DDPSLGDKAA RAVVYFVAMV YMFLGLSIIA DRFMASIEVI TSKEKEITIT KANGETSVGT 120
VRIWNETVSN LTLMALGSSA PEILLSVIEV CGHNFQAGEL GPGTIVGSAA FNMFVVIAVC 180
VYVIPAGESR KIKHLRVFFV TASWSIFAYV WLYLILAVFS PGVVQVWEAL LTLVFFPVCV 240
VFAWMADKRL LFYKYVYKRY RTDPRSGIII GAEGDPPKSI ELDGTFVGTE VPGELGALGT 300
GPAEARELDA SRREVIQILK DLKQKHPDKD LEQLVGIAKY YALLHQQKSR AFYRIQATRL 360
MTGAGNVLRR HAADAARRPG ANDGAPDDED DGASRIFFEP SLYHCLENCG SVLLSVACQG 420
GEGNSTFYVD YRTEDGSAKA GSDYEYSEGT LVFKPGETQK ELRIGIIDDD IFEEDEHFFV 480
RLLNLRVGDA QGMFEPDGGG RPKGRLVAPL LATVTILDDD HAGIFSFQDR LLHVSECMGT 540
VDVRVVRSSG ARGTVRLPYR TVDGTARGGG VHYEDACGEL EFGDDETMKT LQVKIVDDEE 600
YEKKDNFFIE LGQPQWLKRG ISALLLNQGD GDRKLTAEEE EAQRIAEMGK PVLGENCRLE 660
VIIEESYDFK NTVDKLIKKT NLALVIGTHS WREQFLEAVT VSAGDEEEDE DGSREERLPS 720
CFDYVMHFLT VFWKVLFACL PPTEYCHGWA CFGVCILVIG LLTALIGDLA SHFGCTVGLK 780
DSVNAVVFVA LGTSIPDTFA SKVAALQDQC ADASIGNVTG SNAVNVFLGL GVAWSVAAVY 840
WAVQGRPFEV RTGTLAFSVT LFTVFAFVGI AVLLYRRRPH IGGELGGPRG PKLATTALFL 900
GLWFLYILFA SLEAYCHIRG F 921 
Gene Ontology
 GO:0043197; C:dendritic spine; IDA:RGD.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005874; C:microtubule; IDA:RGD.
 GO:0005739; C:mitochondrion; IDA:RGD.
 GO:0043025; C:neuronal cell body; IDA:RGD.
 GO:0005886; C:plasma membrane; IDA:RGD.
 GO:0005432; F:calcium:sodium antiporter activity; IDA:RGD.
 GO:1990034; P:calcium ion export from cell; IDA:RGD.
 GO:1990035; P:calcium ion import into cell; IDA:RGD.
 GO:0060402; P:calcium ion transport into cytosol; IDA:RGD.
 GO:0007154; P:cell communication; IEA:InterPro.
 GO:0033280; P:response to vitamin D; IEP:RGD.
 GO:0021537; P:telencephalon development; IEP:RGD. 
Interpro
 IPR003644; Calx_beta.
 IPR004836; Na_Ca_Ex.
 IPR004837; NaCa_Exmemb. 
Pfam
 PF03160; Calx-beta
 PF01699; Na_Ca_ex 
SMART
 SM00237; Calx_beta 
PROSITE
  
PRINTS
 PR01259; NACAEXCHNGR.