CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007072
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 40S ribosomal protein SA 
Protein Synonyms/Alias
 37 kDa laminin receptor precursor; 37LRP; 37/67 kDa laminin receptor; LRP/LR; 67 kDa laminin receptor; 67LR; Laminin receptor 1; LamR; Laminin-binding protein precursor p40; LBP/p40 
Gene Name
 Rpsa 
Gene Synonyms/Alias
 Lamr1 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
52GIYIINLKRTWEKLLacetylation[1]
89TGQRAVLKFAAATGAubiquitination[2]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113
Functional Description
 Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA (By similarity). 
Sequence Annotation
 REPEAT 230 232 [DE]-W-[ST] 1.
 REPEAT 247 249 [DE]-W-[ST] 2.
 REPEAT 266 268 [DE]-W-[ST] 3.
 REPEAT 275 277 [DE]-W-[ST] 4.
 REPEAT 293 295 [DE]-W-[ST] 5.
 REGION 54 113 Interaction with PPP1R16B (By
 REGION 161 180 Laminin-binding (By similarity).
 REGION 205 229 Laminin-binding (By similarity).
 REGION 242 295 Laminin-binding (By similarity).
 MOD_RES 2 2 N-acetylserine.
 MOD_RES 43 43 Phosphoserine (By similarity).
 MOD_RES 52 52 N6-acetyllysine (By similarity).
 MOD_RES 139 139 Phosphotyrosine (By similarity).  
Keyword
 Acetylation; Cell membrane; Complete proteome; Cytoplasm; Direct protein sequencing; Membrane; Nucleus; Phosphoprotein; Receptor; Reference proteome; Repeat; Ribonucleoprotein; Ribosomal protein. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 295 AA 
Protein Sequence
MSGGLDVLQM KEEDVLKFLA AGTHLGGTNL DFQMEQYIYK RKSDGIYIIN LKRTWEKLLL 60
AARAIVAIEN PADVSVISSR NTGQRAVLKF AAATGATPIA GRFTPGTFTN QIQAAFREPR 120
LLVVTDPRAD HQPLTEASYV NLPTIALCNT DSPLRYVDIA IPCNNKGAHS VGLMWWMLAR 180
EVLRMRGTIS REHPWEVMPD LYFYRDPEEI EKEEQAAAEK AVTKEEFQGE WTAPAPEFTA 240
AQPEVADWSE GVQVPSVPIQ QFPTEDWSAQ PATEDWSAAP TAQATEWVGA TTEWS 295 
Gene Ontology
 GO:0030686; C:90S preribosome; IBA:RefGenome.
 GO:0005604; C:basement membrane; IDA:RGD.
 GO:0022627; C:cytosolic small ribosomal subunit; IDA:RGD.
 GO:0043025; C:neuronal cell body; IDA:RGD.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; ISS:UniProtKB.
 GO:0005055; F:laminin receptor activity; TAS:RGD.
 GO:0003735; F:structural constituent of ribosome; IBA:RefGenome.
 GO:0016337; P:cell-cell adhesion; IDA:RGD.
 GO:0000447; P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:RefGenome.
 GO:0000461; P:endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:RefGenome.
 GO:0030855; P:epithelial cell differentiation; IEP:RGD.
 GO:0000028; P:ribosomal small subunit assembly; IBA:RefGenome.
 GO:0006407; P:rRNA export from nucleus; IBA:RefGenome.
 GO:0006412; P:translation; IBA:RefGenome. 
Interpro
 IPR027504; 40S_ribosomal_SA.
 IPR001865; Ribosomal_S2.
 IPR018130; Ribosomal_S2_CS.
 IPR027498; Ribosomal_S2_euk.
 IPR005707; Ribosomal_S2_euk/arc.
 IPR023591; Ribosomal_S2_flav_dom. 
Pfam
 PF00318; Ribosomal_S2 
SMART
  
PROSITE
 PS00962; RIBOSOMAL_S2_1
 PS00963; RIBOSOMAL_S2_2 
PRINTS
 PR00395; RIBOSOMALS2.