CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021655
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger protein 160 
Protein Synonyms/Alias
 Zinc finger protein HZF5; Zinc finger protein Kr18; HKr18 
Gene Name
 ZNF160 
Gene Synonyms/Alias
 KIAA1611 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
563RGIHSGEKPYKCNECacetylation[1]
591WRVHTGEKPYKCNDCacetylation[1]
594HTGEKPYKCNDCGRAacetylation[1]
768YRCTECGKAFRVRSSubiquitination[2]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 May be involved in transcriptional regulation. 
Sequence Annotation
 DOMAIN 8 79 KRAB.
 ZN_FING 257 279 C2H2-type 1.
 ZN_FING 285 307 C2H2-type 2.
 ZN_FING 313 335 C2H2-type 3.
 ZN_FING 341 363 C2H2-type 4.
 ZN_FING 369 391 C2H2-type 5.
 ZN_FING 397 419 C2H2-type 6.
 ZN_FING 425 447 C2H2-type 7.
 ZN_FING 453 475 C2H2-type 8.
 ZN_FING 481 503 C2H2-type 9.
 ZN_FING 509 531 C2H2-type 10.
 ZN_FING 537 559 C2H2-type 11.
 ZN_FING 565 587 C2H2-type 12.
 ZN_FING 593 615 C2H2-type 13.
 ZN_FING 621 643 C2H2-type 14.
 ZN_FING 649 671 C2H2-type 15.
 ZN_FING 677 699 C2H2-type 16.
 ZN_FING 705 727 C2H2-type 17.
 ZN_FING 733 755 C2H2-type 18.
 ZN_FING 761 783 C2H2-type 19.
 ZN_FING 789 811 C2H2-type 20.  
Keyword
 Complete proteome; DNA-binding; Metal-binding; Nucleus; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 818 AA 
Protein Sequence
MALTQVRLTF RDVAIEFSQE EWKCLDPAQR ILYRDVMLEN YWNLVSLGLC HFDMNIISML 60
EEGKEPWTVK SCVKIARKPR TPECVKGVVT DIPPKCTIKD LLPKEKSSTE AVFHTVVLER 120
HESPDIEDFS FKEPQKNVHD FECQWRDDTG NYKGVLMAQK EGKRDQRDRR DIENKLMNNQ 180
LGVSFHSHLP ELQLFQGEGK MYECNQVEKS TNNGSSVSPL QQIPSSVQTH RSKKYHELNH 240
FSLLTQRRKA NSCGKPYKCN ECGKAFTQNS NLTSHRRIHS GEKPYKCSEC GKTFTVRSNL 300
TIHQVIHTGE KPYKCHECGK VFRHNSYLAT HRRIHTGEKP YKCNECGKAF RGHSNLTTHQ 360
LIHTGEKPFK CNECGKLFTQ NSHLISHWRI HTGEKPYKCN ECGKAFSVRS SLAIHQTIHT 420
GEKPYKCNEC GKVFRYNSYL GRHRRVHTGE KPYKCNECGK AFSMHSNLAT HQVIHTGTKP 480
FKCNECSKVF TQNSQLANHR RIHTGEKPYK CNECGKAFSV RSSLTTHQAI HSGEKPYKCI 540
ECGKSFTQKS HLRSHRGIHS GEKPYKCNEC GKVFAQTSQL ARHWRVHTGE KPYKCNDCGR 600
AFSDRSSLTF HQAIHTGEKP YKCHECGKVF RHNSYLATHR RIHTGEKPYK CNECGKAFSM 660
HSNLTTHKVI HTGEKPYKCN QCGKVFTQNS HLANHQRTHT GEKPYRCNEC GKAFSVRSSL 720
TTHQAIHTGK KPYKCNECGK VFTQNAHLAN HRRIHTGEKP YRCTECGKAF RVRSSLTTHM 780
AIHTGEKRYK CNECGKVFRQ SSNLASHHRM HTGEKPYK 818 
Gene Ontology
 GO:0005634; C:nucleus; NAS:UniProtKB.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0030097; P:hemopoiesis; NAS:UniProtKB.
 GO:0006355; P:regulation of transcription, DNA-dependent; NAS:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR001909; Krueppel-associated_box.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF01352; KRAB 
SMART
 SM00349; KRAB
 SM00355; ZnF_C2H2 
PROSITE
 PS50805; KRAB
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS