CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032230
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Potassium voltage-gated channel subfamily KQT member 2 
Protein Synonyms/Alias
  
Gene Name
 Kcnq2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
463ITDKDRTKGPAETELubiquitination[1]
492KQVLSMEKKLDFLVSubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Ion channel; Ion transport; Membrane; Potassium; Potassium channel; Potassium transport; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 726 AA 
Protein Sequence
IKEYEKSSEG ALYILEIVTI VVFGVEYFVR IWAAGCCCRY RGWRGRLKFA RKPFCVIDIM 60
VLIASIAVLA AGSQGNVFAT SALRSLRFLQ ILRMIRMDRR GGTWKLLGSV VYAHSKELVT 120
AWYIGFLCLI LASFLVYLAE KGENDHFDTY ADALWWGLIT LTTIGYGDKY PQTWNGRLLA 180
ATFTLIGVSF FALPAGILGS GFALKVQEQH RQKHFEKRRN PAAGLIQSAW RFYATNLSRT 240
DLHSTWQYYE RTVTVPMYSS QTQTYGASRL IPPLNQLELL RNLKSKSGLT FRKEPQPEPS 300
PSPRGMAAKG KGSPQAQTVR RSPSADQSLD DSPSKVPKSW SFGDRSRTRQ AFRIKGAASR 360
QNSEEASLPG EDIVEDNKSC NCEFVTEDLT PGLKVSIRAV CVMRFLVSKR KFKESLRPYD 420
VMDVIEQYSA GHLDMLSRIK SLQSRVDQIV GRGPTITDKD RTKGPAETEL PEDPSMMGRL 480
GKVEKQVLSM EKKLDFLVSI YTQRMGIPPA ETEAYFGAKE PEPAPPYHSP EDSRDHADKH 540
GCIIKIVRST SSTGQRNYAA PPAIPPAQCP PSTSWQQSHQ RHGTSPVGDH GSLVRIPPPP 600
AHERSLSAYG GGNRASTEFL RLEGTPACRP SEAALRDSDT SISIPSVDHE ELERSFSGFS 660
ISQSKENLDA LGSCYAAVAP CAKVRPYIAE GESDTDSDLC TPCGPPPRSA TGEGPFGDVA 720
WAGPRK 726 
Gene Ontology
 GO:0008076; C:voltage-gated potassium channel complex; IEA:InterPro.
 GO:0005251; F:delayed rectifier potassium channel activity; IBA:RefGenome.
 GO:0019226; P:transmission of nerve impulse; IMP:MGI. 
Interpro
 IPR020969; Ankyrin-G_BS.
 IPR005821; Ion_trans_dom.
 IPR003091; K_chnl.
 IPR003937; K_chnl_volt-dep_KCNQ.
 IPR013821; K_chnl_volt-dep_KCNQ_C. 
Pfam
 PF00520; Ion_trans
 PF03520; KCNQ_channel
 PF11956; KCNQC3-Ank-G_bd 
SMART
  
PROSITE
  
PRINTS
 PR00169; KCHANNEL.
 PR01459; KCNQCHANNEL.