| Tag | Content |
|---|
| CPLM ID | CPLM-010499 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | N-acylglucosamine 2-epimerase |
Protein Synonyms/Alias | AGE; GlcNAc 2-epimerase; N-acetyl-D-glucosamine 2-epimerase; Renin-binding protein; RnBP |
Gene Name | Renbp |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 23 | RETLQVWKKRVEQEL | ubiquitination | [1] | | 245 | ENVSEDGKELPGCLG | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Catalyzes the interconversion of N-acetylglucosamine to N-acetylmannosamine. Binds to renin forming a protein complex called high molecular weight (HMW) renin and inhibits renin activity. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. |
Sequence Annotation | REGION 196 217 Leucine-zipper. |
Keyword | Alternative splicing; Complete proteome; Isomerase; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 430 AA |
Protein Sequence | MMDLGLLMLQ DMEKERETLQ VWKKRVEQEL DRVIAFWMEH SHDQEHGGFF TCLGRDGKVY 60
DHLKYVWLQG RQVWMYCRLY RSFERFRRVE LLDAARAGGE FLLRYARVAP PGKKCAFVLT 120
RDGRPVKVQR TIFSECFYTM AMNELWKVTG EVRYQSEAIE MMDQIIHWVR EDPAGLGRPQ 180
LSGALATEPM AVPMMLLSLV EQLGEEDEEL TNMYAELGDW CVHRILQHVQ RDGQVVLENV 240
SEDGKELPGC LGRHQNPGHT LEAGWFLLQY ALRKGDPKLR MHIIDKFLLL PFHSGWDPEH 300
GGLFYFQDAD GLCPTQLEWN MKLWWPHSEA MIAFLMGYSD SGDPALLHLF YKVAEYTFRQ 360
FRDPEYGEWF GYLNQEGKVA LTIKGGPFKG CFHVPRCLAM CEQILGALLQ RLEPAPLDSS 420
PAVSTHEGSK 430 |
Gene Ontology | GO:0005524; F:ATP binding; IEA:Compara. GO:0004857; F:enzyme inhibitor activity; IEA:Compara. GO:0004476; F:mannose-6-phosphate isomerase activity; IEA:InterPro. GO:0050121; F:N-acylglucosamine 2-epimerase activity; IDA:UniProtKB. GO:0006013; P:mannose metabolic process; IEA:InterPro. GO:0006044; P:N-acetylglucosamine metabolic process; IMP:MGI. GO:0006051; P:N-acetylmannosamine metabolic process; IEA:Compara. GO:0019262; P:N-acetylneuraminate catabolic process; TAS:UniProtKB. GO:0010951; P:negative regulation of endopeptidase activity; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |