CPLM-014613

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-014613

UniProt Accession

CLCN1_MOUSE; Q64347; Q8BZ41; Q9QVY5

Genbank Protein ID

Z95127; Z95128; Z95129; Z95130; Z95131; Z95132; Z95133; Z95134; Z95135; Z95136; Z95137; Z95138; Z95139; Z95140; Z95141; Z95142; Z95143; Z95144; Z95145; Z95146; Z95147; Z95148; Z95149; AK036735; CH466533; BC114336; X62895; X62896; X62897

Genbank Nucleotide ID

CAB08359.1; CAB08359.1; CAB08359.1; CAB08359.1; CAB08359.1; CAB08359.1; CAB08359.1; CAB08359.1; CAB08359.1; CAB08359.1; CAB08359.1; CAB08359.1; CAB08359.1; CAB08359.1; CAB08359.1; CAB08359.1; CAB08359.1; CAB08359.1; CAB08359.1; CAB08359.1; CAB08359.1; CAB08359.1; CAB08359.1; BAC29557.1; EDL13488.1; AAI14337.1; CAA44684.1; CAA44685.1; CAA44686.1

Protein Name

Chloride channel protein 1

Protein Synonyms/Alias

ClC-1; Chloride channel protein, skeletal muscle

Gene Name

Clcn1

Gene Synonyms/Alias

Clc1

Created Date

July 27, 2013

Organism

Mus musculus (Mouse)

NCBI Taxa ID

10090

Lysine Modification

Position	Peptide	Type	References
72	QKEQYSYKAQDGGMP	ubiquitination	[1]

Reference

[1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]

Functional Description

Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport.

Sequence Annotation

DOMAIN 609 668 CBS 1.
DOMAIN 827 882 CBS 2.
MOTIF 188 192 Selectivity filter part_1 (By
MOTIF 230 234 Selectivity filter part_2 (By
MOTIF 482 486 Selectivity filter part_3 (By
BINDING 189 189 Chloride (By similarity).
BINDING 578 578 Chloride (By similarity).

Keyword

CBS domain; Chloride; Chloride channel; Complete proteome; Ion channel; Ion transport; Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport; Voltage-gated channel.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

994 AA

Protein Sequence

MERSQSQRHG GEQSWWGSAP QYQYMPFEHC TSYGLPSENG GLQHRPRKDM GPRHNAHPTQ 60
IYGHQKEQYS YKAQDGGMPK KMGSSSTMDS LDEDHYSKCQ DCVHRLGRVL RRKLGEDWIF 120
LVLLGLLMAL VSWCMDYVSA KSLQAYKWTY AQMKPSLPLQ YLAWVTFPLI LILFSALFCQ 180
LISPQAVGSG IPEMKTILRG VVLKEYLTLK AFVAKVVALT AGLGSGIPVG KEGPFVHIAS 240
ICAAVLSKFM SMFSGVYEQP YYYTDILTVG CAVGVGCCFG TPLGGVLFSI EVTSTYFAVR 300
NYWRGFFAAT FSAFVFRVLA VWNKDAVTIT ALFRTNFRMD FPFDLKELPA FAVIGICCGF 360
LGAVFVYLHR QVMLGVRKHK CLSQFLAKHR LLYPGIVTFV IASLTFPPGM GQFMAGELMP 420
REAISTLFDN NTWVKHIGDP QSLGQSAVWL HPQVNVIIII LLFFVMKFWM SIVATTMPIP 480
CGGFMPVFVL GAAFGRLVGE IMAMLFPEGI LFDDIIYKIL PGGYAVIGAA ALTGAVSHTV 540
STAVICFELT GQIAHILPMM VAVILANMVA QSLQPSLYDS IIQVKKLPYL PDLGWNQLSK 600
FTIFVEDIMV RDVKFVSASC TYGELRNLLQ ATTVKTLPLV DSKDSMILLG SVERSELQSL 660
LQRHLCAERR LKAAQDMARK LSELPYNGKA QLAGDWHPGG RPESFAFVDE DEDEDLSRKM 720
ELPLTPAPPP PSPPPPPSQF PIAPSNPEEP NGPLPSHKQP PEASDSADQR SSTFQRLLHC 780
LLGKAHSKKK KITQDSTDLV DNMSPEEIEA WEREQLSQPV CFDCCCIDQS PFQLVEQTTL 840
HKTHTLFSLL GLHLAYVTSM GKLRGVLALE ELQKAIEGHT KSGVQLRPPL ASFRNTTSIR 900
KTPGGPPPPA EGWNVPEDGD GAPGREVMVP TMPETPVPPP SPEAPSCLAP ARAEGELEEL 960
EMVGSLEPEE ELADILHGPS LRSTDEEDED ELIL 994

Gene Ontology

GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
GO:0042383; C:sarcolemma; IDA:MGI.
GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro.
GO:0006821; P:chloride transport; IMP:MGI.
GO:0019227; P:neuronal action potential propagation; IMP:MGI.

Interpro

IPR014743; Cl-channel_core.
IPR001807; Cl-channel_volt-gated.
IPR002243; Cl_channel-1.
IPR000644; Cysta_beta_synth_core.

Pfam

PF00571; CBS
PF00654; Voltage_CLC

SMART

PROSITE

PS51371; CBS

PRINTS

PR00762; CLCHANNEL.
PR01112; CLCHANNEL1.