CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017600
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Plasminogen activator inhibitor 1 RNA-binding protein 
Protein Synonyms/Alias
 PAI1 RNA-binding protein 1; PAI-RBP1; SERPINE1 mRNA-binding protein 1 
Gene Name
 SERBP1 
Gene Synonyms/Alias
 PAIRBP1; CGI-55 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
32SDPFEVLKAAENKKKubiquitination[1]
52GVGGPGAKSAAQAAAubiquitination[1]
68TNSNAAGKQLRKESQubiquitination[1]
234ESPKYIQKQISYNYSubiquitination[1]
314EGADGQWKKGFVLHKubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
 May play a role in the regulation of mRNA stability. Binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay. 
Sequence Annotation
 MOD_RES 25 25 Phosphoserine.
 MOD_RES 68 68 N6-acetyllysine.
 MOD_RES 122 122 N6-acetyllysine.
 MOD_RES 140 140 N6-acetyllysine.
 MOD_RES 211 211 N6-acetyllysine.
 MOD_RES 234 234 Phosphoserine.
 MOD_RES 244 244 Phosphotyrosine (By similarity).
 MOD_RES 252 252 Phosphoserine (By similarity).
 MOD_RES 330 330 Phosphoserine.
 MOD_RES 391 391 Phosphoserine (By similarity).
 MOD_RES 392 392 Phosphoserine.
 MOD_RES 394 394 Phosphoserine.  
Keyword
 3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Nucleus; Phosphoprotein; Reference proteome; RNA-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 408 AA 
Protein Sequence
MPGHLQEGFG CVVTNRFDQL FDDESDPFEV LKAAENKKKE AGGGGVGGPG AKSAAQAAAQ 60
TNSNAAGKQL RKESQKDRKN PLPPSVGVVD KKEETQPPVA LKKEGIRRVG RRPDQQLQGE 120
GKIIDRRPER RPPRERRFEK PLEEKGEGGE FSVDRPIIDR PIRGRGGLGR GRGGRGRGMG 180
RGDGFDSRGK REFDRHSGSD RSGLKHEDKR GGSGSHNWGT VKDELTESPK YIQKQISYNY 240
SDLDQSNVTE ETPEGEEHHP VADTENKENE VEEVKEEGPK EMTLDEWKAI QNKDRAKVEF 300
NIRKPNEGAD GQWKKGFVLH KSKSEEAHAE DSVMDHHFRK PANDITSQLE INFGDLGRPG 360
RGGRGGRGGR GRGGRPNRGS RTDKSSASAP DVDDPEAFPA LA 402 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0003730; F:mRNA 3'-UTR binding; IDA:HGNC.
 GO:0043488; P:regulation of mRNA stability; NAS:HGNC. 
Interpro
 IPR006861; HABP4_PAIRBP1-bd.
 IPR027205; SERBP1. 
Pfam
 PF04774; HABP4_PAI-RBP1 
SMART
  
PROSITE
  
PRINTS