CPLM-008340

Genbank Nucleotide ID

60S ribosomal protein L14

Protein Synonyms/Alias

Homo sapiens (Human)

Position	Peptide	Type	References
23	SFGPHAGKLVAIVDV	ubiquitination	[1, 2, 3]
53	RRQAMPFKCMQLTDF	ubiquitination	[2]
63	QLTDFILKFPHSAHQ	ubiquitination	[2, 3]
71	FPHSAHQKYVRQAWQ	acetylation	[4]
71	FPHSAHQKYVRQAWQ	ubiquitination	[1, 2]
79	YVRQAWQKADINTKW	acetylation	[4]
79	YVRQAWQKADINTKW	ubiquitination	[1, 2, 3]
85	QKADINTKWAATRWA	acetylation	[4]
85	QKADINTKWAATRWA	ubiquitination	[1, 2, 3, 5, 6]
101	KIEARERKAKMTDFD	ubiquitination	[1, 2]
103	EARERKAKMTDFDRF	ubiquitination	[1, 2]
124	KMRNRIIKNEVKKLQ	ubiquitination	[2, 7]
129	IIKNEVKKLQKAALL	ubiquitination	[2, 8]
132	NEVKKLQKAALLKAS	ubiquitination	[2, 8]
137	LQKAALLKASPKKAP	ubiquitination	[2, 5, 7, 8]
165	AAKVPAKKITAASKK	ubiquitination	[5]
187	AQKATGQKAAPAPKA	acetylation	[9]
193	QKAAPAPKAQKGQKA	acetylation	[9]
196	APAPKAQKGQKAPAQ	acetylation	[9]

[1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
[2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
[3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
[4] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
[5] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
[6] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572]
[7] Integrated proteomic analysis of post-translational modifications by serial enrichment.
Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
[8] Global identification of modular cullin-RING ligase substrates.
Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
[9] Regulation of cellular metabolism by protein lysine acetylation.
Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]

Functional Description

REPEAT 171 175 1-1.
REPEAT 176 180 1-2.
REPEAT 181 185 1-3.
REPEAT 186 190 1-4.
REPEAT 193 195 2-1.
REPEAT 196 198 2-2.
REGION 171 190 4 X 5 AA tandem repeats of Q-K-A-[PAS]-X.
REGION 193 198 2 X 3 AA tandem repeats of K-[GA]-Q.
MOD_RES 79 79 N6-acetyllysine.
MOD_RES 85 85 N6-acetyllysine.
MOD_RES 139 139 Phosphoserine.

3D-structure; Acetylation; Complete proteome; Direct protein sequencing; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Ribonucleoprotein; Ribosomal protein; Triplet repeat expansion.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0022625; C:cytosolic large ribosomal subunit; IDA:UniProtKB.
GO:0003723; F:RNA binding; TAS:ProtInc.
GO:0003735; F:structural constituent of ribosome; NAS:UniProtKB.
GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; TAS:Reactome.
GO:0042273; P:ribosomal large subunit biogenesis; IMP:UniProtKB.
GO:0006364; P:rRNA processing; IMP:UniProtKB.
GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; TAS:Reactome.
GO:0006414; P:translational elongation; TAS:Reactome.
GO:0006413; P:translational initiation; TAS:Reactome.
GO:0006415; P:translational termination; TAS:Reactome.
GO:0019083; P:viral transcription; TAS:Reactome.

IPR014722; Rib_L2_dom2.
IPR002784; Ribosomal_L14.

PF01929; Ribosomal_L14e