UniProt Accession

 MATR3_MOUSE; Q8K310 

Genbank Protein ID

 AK087939; BC029070 

Genbank Nucleotide ID

 BAC40050.1; AAH29070.1 

Protein Name

 Matrin-3 

Protein Synonyms/Alias

  

Gene Name

 Matr3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
3	*****MSKSFQQSSL	acetylation	[1, 2]
146	PQILLQLKRRRTEEG	acetylation	[1]
491	PDQKFDQKQELGRVI	acetylation	[2]
491	PDQKFDQKQELGRVI	ubiquitination	[3]
515	YSDSAVLKLAEPYGK	acetylation	[1]
515	YSDSAVLKLAEPYGK	ubiquitination	[3]
522	KLAEPYGKIKNYILM	acetylation	[2]
522	KLAEPYGKIKNYILM	succinylation	[2]
522	KLAEPYGKIKNYILM	ubiquitination	[3]
555	MVDHCLKKALWFQGR	ubiquitination	[3]
835	KLKKFLNKLAEERRQ	acetylation	[1, 2]
835	KLKKFLNKLAEERRQ	ubiquitination	[3]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs (By similarity). 

Sequence Annotation

 DOMAIN 398 473 RRM 1.
 DOMAIN 496 571 RRM 2.
 ZN_FING 800 831 Matrin-type.
 MOTIF 709 717 Nuclear localization signal (Potential).
 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 3 3 N6-acetyllysine (By similarity).
 MOD_RES 4 4 Phosphoserine (By similarity).
 MOD_RES 9 9 Phosphoserine (By similarity).
 MOD_RES 14 14 Phosphoserine (By similarity).
 MOD_RES 22 22 Phosphoserine (By similarity).
 MOD_RES 41 41 Phosphoserine (By similarity).
 MOD_RES 118 118 Phosphoserine (By similarity).
 MOD_RES 188 188 Phosphoserine.
 MOD_RES 195 195 Phosphoserine (By similarity).
 MOD_RES 206 206 Phosphoserine (By similarity).
 MOD_RES 208 208 Phosphoserine (By similarity).
 MOD_RES 219 219 Phosphotyrosine (By similarity).
 MOD_RES 522 522 N6-acetyllysine (By similarity).
 MOD_RES 533 533 Phosphoserine (By similarity).
 MOD_RES 571 571 N6-acetyllysine (By similarity).
 MOD_RES 596 596 Phosphoserine (By similarity).
 MOD_RES 598 598 Phosphoserine.
 MOD_RES 604 604 Phosphoserine (By similarity).
 MOD_RES 606 606 Phosphoserine (By similarity).
 MOD_RES 740 740 Phosphothreonine (By similarity).
 MOD_RES 746 746 Phosphoserine (By similarity).
 MOD_RES 835 835 N6-acetyllysine (By similarity).  

Keyword

 3D-structure; Acetylation; Complete proteome; Direct protein sequencing; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; RNA-binding; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 846 AA 

Protein Sequence

Gene Ontology

 GO:0016363; C:nuclear matrix; IEA:UniProtKB-SubCell.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro. 

Interpro

 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom.
 IPR015880; Znf_C2H2-like.
 IPR000690; Znf_C2H2_matrin.
 IPR003604; Znf_U1. 

Pfam

  

SMART

 SM00360; RRM
 SM00355; ZnF_C2H2
 SM00451; ZnF_U1 

PROSITE

 PS50102; RRM
 PS50171; ZF_MATRIN 

PRINTS