CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015465
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cytochrome P450 2C54 
Protein Synonyms/Alias
 CYPIIC54 
Gene Name
 Cyp2c54 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
28RQSYERGKLPPGPTPubiquitination[1]
72YTLYLGRKPTVVLHGubiquitination[1]
84LHGYEAVKEALVDHGubiquitination[1]
105GRLPVFDKATNGMGIubiquitination[1]
121FSNGSVWKNTRHFSLubiquitination[1]
190FQDRFDYKDRDFLNLubiquitination[1]
200DFLNLLEKLDEISKIubiquitination[1]
241FKNYAYIKNFLLEKIubiquitination[1]
247IKNFLLEKIREHKESubiquitination[1]
252LEKIREHKESLDVTIubiquitination[1]
270FIDYFLIKGAQEDDNubiquitination[1]
375HEVTCDIKFRNYFIPubiquitination[1]
383FRNYFIPKGTTVITSubiquitination[1]
399SSVLRDSKEFPNPEKubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Metabolizes arachidonic acid mainly to 12- hydroxyeicosatetraenoic acid (HETE). 
Sequence Annotation
 METAL 435 435 Iron (heme axial ligand) (By similarity).  
Keyword
 Complete proteome; Endoplasmic reticulum; Heme; Iron; Membrane; Metal-binding; Microsome; Monooxygenase; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 490 AA 
Protein Sequence
MDPILVLVLT LSCLFLLSLW RQSYERGKLP PGPTPLPIIG NILQIDVKDI CQSFTNLSRV 60
YGPVYTLYLG RKPTVVLHGY EAVKEALVDH GDVFAGRGRL PVFDKATNGM GIGFSNGSVW 120
KNTRHFSLMT LRNLGMGKRS IEDRVQEEAR CLVEELRKTN GSPCDPTFIL GCAPCNVICS 180
IIFQDRFDYK DRDFLNLLEK LDEISKILST PWLQVCNTFP ALLDYCPGSH NQFFKNYAYI 240
KNFLLEKIRE HKESLDVTIP RDFIDYFLIK GAQEDDNHPL KNNFEHLAIT VTDLFIGGTE 300
SMSTTLRYAL LLLLKYPHVT AKVQEEIEHV IGKHRRPCMQ DRSHMPYTNA MIHEVQRFID 360
LVPNNLPHEV TCDIKFRNYF IPKGTTVITS LSSVLRDSKE FPNPEKFDPG HFLDENGKFK 420
KSDYFMPFST GKRICAGEGL ARMELFLFLT SILQNFNLKP LVHPKDIDIT PMLIGLGSVP 480
PAFQLCFIPS 490 
Gene Ontology
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0070330; F:aromatase activity; IEA:EC.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0005506; F:iron ion binding; IEA:InterPro. 
Interpro
 IPR001128; Cyt_P450.
 IPR017972; Cyt_P450_CS.
 IPR002401; Cyt_P450_E_grp-I. 
Pfam
 PF00067; p450 
SMART
  
PROSITE
 PS00086; CYTOCHROME_P450 
PRINTS
 PR00463; EP450I.
 PR00385; P450.