CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037684
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 NDUFS8 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
31QDPEMDMKSVTDRAAmethylation[1]
31QDPEMDMKSVTDRAAubiquitination[2]
70TINYPFEKGPLSPRFubiquitination[2, 3, 4]
Reference
 [1] Mass spectrometry-based identification and characterisation of lysine and arginine methylation in the human proteome.
 Bremang M, Cuomo A, Agresta AM, Stugiewicz M, Spadotto V, Bonaldi T.
 Mol Biosyst. 2013 Jul 30;9(9):2231-47. [PMID: 23748837]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 138 AA 
Protein Sequence
MRRPLCATGL VRVGDHWEEY VNMQDPEMDM KSVTDRAART LLWTELFRGL GMTLSYLFRE 60
PATINYPFEK GPLSPRFRGE HALRRYPSGE ERCIACKLCE AICPAQAITI EAEPRADGSR 120
RTTRYDIDMT KCIYCGFC 138 
Gene Ontology
 GO:0016020; C:membrane; IEA:InterPro.
 GO:0005739; C:mitochondrion; IDA:HPA.
 GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:InterPro.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0016651; F:oxidoreductase activity, acting on NAD(P)H; IEA:InterPro. 
Interpro
 IPR001450; 4Fe4S-bd_dom.
 IPR017896; 4Fe4S_Fe-S-bd.
 IPR017900; 4Fe4S_Fe_S_CS.
 IPR012285; Fum_reductase_C.
 IPR010226; NADH_quinone_OxRdtase_chainI. 
Pfam
 PF12838; Fer4_7 
SMART
  
PROSITE
 PS00198; 4FE4S_FER_1
 PS51379; 4FE4S_FER_2 
PRINTS