| Tag | Content |
|---|
| CPLM ID | CPLM-019363 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Leucine-rich repeats and immunoglobulin-like domains protein 1 |
Protein Synonyms/Alias | LIG-1 |
Gene Name | LRIG1 |
Gene Synonyms/Alias | LIG1 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 603 | NVLPSFTKTPHDITI | ubiquitination | [1] | | 634 | NPQIAWQKDGGTDFP | ubiquitination | [1] | | 715 | ETVALQCKATGNPPP | ubiquitination | [1] | | 728 | PPRITWFKGDRPLSL | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation. |
Sequence Annotation | DOMAIN 35 68 LRRNT.
REPEAT 69 90 LRR 1.
REPEAT 93 114 LRR 2.
REPEAT 116 137 LRR 3.
REPEAT 140 161 LRR 4.
REPEAT 164 185 LRR 5.
REPEAT 189 210 LRR 6.
REPEAT 212 233 LRR 7.
REPEAT 236 257 LRR 8.
REPEAT 260 281 LRR 9.
REPEAT 284 305 LRR 10.
REPEAT 308 329 LRR 11.
REPEAT 332 353 LRR 12.
REPEAT 356 378 LRR 13.
REPEAT 383 404 LRR 14.
REPEAT 407 428 LRR 15.
DOMAIN 440 491 LRRCT.
DOMAIN 495 594 Ig-like C2-type 1.
DOMAIN 599 688 Ig-like C2-type 2.
DOMAIN 693 779 Ig-like C2-type 3.
CARBOHYD 74 74 N-linked (GlcNAc...) (Potential).
CARBOHYD 150 150 N-linked (GlcNAc...) (Potential).
CARBOHYD 246 246 N-linked (GlcNAc...) (Potential).
CARBOHYD 292 292 N-linked (GlcNAc...) (Potential).
CARBOHYD 318 318 N-linked (GlcNAc...) (Potential).
CARBOHYD 684 684 N-linked (GlcNAc...) (Potential).
DISULFID 516 577 By similarity.
DISULFID 620 672 By similarity.
DISULFID 714 763 By similarity. |
Keyword | Alternative splicing; Complete proteome; Disulfide bond; Glycoprotein; Immunoglobulin domain; Leucine-rich repeat; Membrane; Polymorphism; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1093 AA |
Protein Sequence | MARPVRGGLG APRRSPCLLL LWLLLLRLEP VTAAAGPRAP CAAACTCAGD SLDCGGRGLA 60
ALPGDLPSWT RSLNLSYNKL SEIDPAGFED LPNLQEVYLN NNELTAVPSL GAASSHVVSL 120
FLQHNKIRSV EGSQLKAYLS LEVLDLSLNN ITEVRNTCFP HGPPIKELNL AGNRIGTLEL 180
GAFDGLSRSL LTLRLSKNRI TQLPVRAFKL PRLTQLDLNR NRIRLIEGLT FQGLNSLEVL 240
KLQRNNISKL TDGAFWGLSK MHVLHLEYNS LVEVNSGSLY GLTALHQLHL SNNSIARIHR 300
KGWSFCQKLH ELVLSFNNLT RLDEESLAEL SSLSVLRLSH NSISHIAEGA FKGLRSLRVL 360
DLDHNEISGT IEDTSGAFSG LDSLSKLTLF GNKIKSVAKR AFSGLEGLEH LNLGGNAIRS 420
VQFDAFVKMK NLKELHISSD SFLCDCQLKW LPPWLIGRML QAFVTATCAH PESLKGQSIF 480
SVPPESFVCD DFLKPQIITQ PETTMAMVGK DIRFTCSAAS SSSSPMTFAW KKDNEVLTNA 540
DMENFVHVHA QDGEVMEYTT ILHLRQVTFG HEGRYQCVIT NHFGSTYSHK ARLTVNVLPS 600
FTKTPHDITI RTTTMARLEC AATGHPNPQI AWQKDGGTDF PAARERRMHV MPDDDVFFIT 660
DVKIDDAGVY SCTAQNSAGS ISANATLTVL ETPSLVVPLE DRVVSVGETV ALQCKATGNP 720
PPRITWFKGD RPLSLTERHH LTPDNQLLVV QNVVAEDAGR YTCEMSNTLG TERAHSQLSV 780
LPAAGCRKDG TTVGIFTIAV VSSIVLTSLV WVCIIYQTRK KSEEYSVTNT DETVVPPDVP 840
SYLSSQGTLS DRQETVVRTE GGPQANGHIE SNGVCPRDAS HFPEPDTHSV ACRQPKLCAG 900
SAYHKEPWKA MEKAEGTPGP HKMEHGGRVV CSDCNTEVDC YSRGQAFHPQ PVSRDSAQPS 960
APNGPEPGGS DQEHSPHHQC SRTAAGSCPE CQGSLYPSNH DRMLTAVKKK PMASLDGKGD 1020
SSWTLARLYH PDSTELQPAS SLTSGSPERA EAQYLLVSNG HLPKACDASP ESTPLTGQLP 1080
GKQRVPLLLA PKS 1093 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |