CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022827
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 COMM domain-containing protein 3 
Protein Synonyms/Alias
 Protein Bup; Protein PIL 
Gene Name
 COMMD3 
Gene Synonyms/Alias
 BUP; C10orf8 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
9ELSESVQKGFQMLADubiquitination[1]
52VLDHPDLKHIDPVVLubiquitination[1]
60HIDPVVLKHCHAAAAubiquitination[1]
75TYILEAGKHRADKSTubiquitination[1]
80AGKHRADKSTLSTYLubiquitination[1]
91STYLEDCKFDRERIEubiquitination[1]
108CTEYQNNKNSLEILLubiquitination[2]
137WRLEYQIKTNQLHRMubiquitination[1, 2, 3, 4]
183QDLVGKLKDASKSLEubiquitination[1]
187GKLKDASKSLERATQubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789
Functional Description
 May down-regulate activation of NF-kappa-B. 
Sequence Annotation
 DOMAIN 124 193 COMM.  
Keyword
 Complete proteome; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 195 AA 
Protein Sequence
MELSESVQKG FQMLADPRSF DSNAFTLLLR AAFQSLLDAQ ADEAVLDHPD LKHIDPVVLK 60
HCHAAAATYI LEAGKHRADK STLSTYLEDC KFDRERIELF CTEYQNNKNS LEILLGSIGR 120
SLPHITDVSW RLEYQIKTNQ LHRMYRPAYL VTLSVQNTDS PSYPEISFSC SMEQLQDLVG 180
KLKDASKSLE RATQL 195 
Gene Ontology
  
Interpro
 IPR017920; COMM.
 IPR009886; HCaRG. 
Pfam
 PF07258; HCaRG 
SMART
  
PROSITE
 PS51269; COMM 
PRINTS