CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005643
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cytosolic 10-formyltetrahydrofolate dehydrogenase 
Protein Synonyms/Alias
 10-FTHFDH; FDH; Aldehyde dehydrogenase family 1 member L1; FBP-CI 
Gene Name
 Aldh1l1 
Gene Synonyms/Alias
 Fthfd 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
479FENGLWGKINARDRGacetylation[1]
733KVVEEVEKMKIGNPLacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
 DOMAIN 323 392 Acyl carrier.
 NP_BIND 571 573 NADP.
 NP_BIND 597 600 NADP.
 NP_BIND 630 635 NADP.
 NP_BIND 650 651 NADP.
 NP_BIND 804 806 NADP.
 REGION 1 203 GART.
 REGION 88 90 Substrate binding (By similarity).
 REGION 417 902 Aldehyde dehydrogenase.
 ACT_SITE 106 106 Proton donor (By similarity).
 ACT_SITE 673 673 Proton acceptor (Probable).
 ACT_SITE 707 707 Proton donor (Probable).
 BINDING 142 142 Substrate (By similarity).
 BINDING 757 757 NADP.
 MOD_RES 354 354 O-(pantetheine 4'-phosphoryl)serine;
 MOD_RES 354 354 Phosphoserine; alternate.  
Keyword
 3D-structure; Complete proteome; Cytoplasm; Direct protein sequencing; NADP; One-carbon metabolism; Oxidoreductase; Phosphopantetheine; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 902 AA 
Protein Sequence
MKIAVIGQSL FGQEVYCQLR KEGHEVVGVF TIPDKDGKAD PLGLEAEKDG VPVFKFPRWR 60
ARGQALPEVV AKYQALGAEL NVLPFCSQFI PMEVINAPRH GSIIYHPSLL PRHRGASAIN 120
WTLIHGDKKG GFTIFWADDG LDTGDLLLQK ECEVLPDDTV STLYNRFLFP EGIKGMVQAV 180
RLIAEGTAPR CPQSEEGATY EGIQKKETAK INWDQPAEAI HNWIRGNDKV PGAWTEACGQ 240
KLTFFNSTLN TSGLSTQGEA LPIPGAHRPG VVTKAGLILF GNDDRMLLVK NIQLEDGKMM 300
PASQFFKGSA SSDLELTEAE LATAEAVRSS WMRILPNVPE VEDSTDFFKS GAASVDVVRL 360
VEEVKELCDG LELENEDVYM ATTFRGFIQL LVRKLRGEDD ESECVINYVE KAVNKLTLQM 420
PYQLFIGGEF VDAEGSKTYN TINPTDGSVI CQVSLAQVSD VDKAVAAAKE AFENGLWGKI 480
NARDRGRLLY RLADVMEQHQ EELATIEALD AGAVYTLALK THVGMSIQTF RYFAGWCDKI 540
QGATIPINQA RPNRNLTLTK KEPVGVCGIV IPWNYPLMML SWKTAACLAA GNTVVIKPAQ 600
VTPLTALKFA ELTLKAGIPK GVVNILPGSG SLVGQRLSDH PDVRKIGFTG STEVGKHIMK 660
SCALSNVKKV SLELGGKSPL IIFADCDLNK AVQMGMSSVF FNKGENCIAA GRLFVEESIH 720
NQFVQKVVEE VEKMKIGNPL ERDTNHGPQN HEAHLRKLVE YCQRGVKEGA TLVCGGNQVP 780
RPGFFFQPTV FTDVEDHMYI AKEESFGPIM IISRFADGDV DAVLSRANAT EFGLASGVFT 840
RDINKALYVS DKLQAGTVFI NTYNKTDVAA PFGGFKQSGF GKDLGEAALN EYLRIKTVTF 900
EY 902 
Gene Ontology
 GO:0005829; C:cytosol; TAS:RGD.
 GO:0043234; C:protein complex; IDA:RGD.
 GO:0033721; F:aldehyde dehydrogenase (NADP+) activity; IDA:UniProtKB.
 GO:0004030; F:aldehyde dehydrogenase [NAD(P)+] activity; IDA:RGD.
 GO:0016155; F:formyltetrahydrofolate dehydrogenase activity; TAS:RGD.
 GO:0016742; F:hydroxymethyl-, formyl- and related transferase activity; IEA:InterPro.
 GO:0008168; F:methyltransferase activity; IEA:InterPro.
 GO:0032403; F:protein complex binding; IDA:RGD.
 GO:0009258; P:10-formyltetrahydrofolate catabolic process; IEA:InterPro.
 GO:0032259; P:methylation; IEA:GOC.
 GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
 GO:0046654; P:tetrahydrofolate biosynthetic process; TAS:RGD. 
Interpro
 IPR011407; 10_FTHF_DH.
 IPR009081; Acyl_carrier_prot-like.
 IPR016161; Ald_DH/histidinol_DH.
 IPR016163; Ald_DH_C.
 IPR016160; Ald_DH_CS.
 IPR016162; Ald_DH_N.
 IPR015590; Aldehyde_DH_dom.
 IPR005793; Formyl_trans_C.
 IPR002376; Formyl_transf_N.
 IPR011034; Formyl_transferase_C-like.
 IPR001555; GART_AS. 
Pfam
 PF00171; Aldedh
 PF02911; Formyl_trans_C
 PF00551; Formyl_trans_N
 PF00550; PP-binding 
SMART
  
PROSITE
 PS50075; ACP_DOMAIN
 PS00070; ALDEHYDE_DEHYDR_CYS
 PS00687; ALDEHYDE_DEHYDR_GLU
 PS00373; GART
 PS00012; PHOSPHOPANTETHEINE 
PRINTS