CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022168
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Gamma-taxilin 
Protein Synonyms/Alias
 Environmental lipopolysaccharide-responding gene protein; Factor inhibiting ATF4-mediated transcription; FIAT; Lipopolysaccharide-specific response protein 5 
Gene Name
 TXLNG 
Gene Synonyms/Alias
 CXorf15; ELRG; LSR5 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
275ENIELGEKLKKLIEQubiquitination[1, 2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 May be involved in intracellular vesicle traffic. Inhibits ATF4-mediated transcription, possibly by dimerizing with ATF4 to form inactive dimers that cannot bind DNA. May be involved in regulating bone mass density through an ATF4-dependent pathway. May be involved in cell cycle progression. 
Sequence Annotation
 MOD_RES 86 86 Phosphoserine.
 MOD_RES 97 97 Phosphoserine.
 MOD_RES 105 105 Phosphoserine.
 MOD_RES 283 283 Phosphotyrosine.
 MOD_RES 517 517 Phosphoserine.  
Keyword
 Alternative splicing; Cell cycle; Coiled coil; Complete proteome; Cytoplasm; Membrane; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 528 AA 
Protein Sequence
MATRVEEAAR GRGGGAEEAT EAGRGGRRRS PRQKFEIGTM EEAGICGLGV KADMLCNSQS 60
NDILQHQGSN CGGTSNKHSL EEDEGSDFIT ENRNLVSPAY CTQESREEIP GGEARTDPPD 120
GQQDSECNRN KEKTLGKEVL LLMQALNTLS TPEEKLAALC KKYADLLEES RSVQKQMKIL 180
QKKQAQIVKE KVHLQSEHSK AILARSKLES LCRELQRHNK TLKEENMQQA REEEERRKEA 240
TAHFQITLNE IQAQLEQHDI HNAKLRQENI ELGEKLKKLI EQYALREEHI DKVFKHKELQ 300
QQLVDAKLQQ TTQLIKEADE KHQREREFLL KEATESRHKY EQMKQQEVQL KQQLSLYMDK 360
FEEFQTTMAK SNELFTTFRQ EMEKMTKKIK KLEKETIIWR TKWENNNKAL LQMAEEKTVR 420
DKEYKALQIK LERLEKLCRA LQTERNELNE KVEVLKEQVS IKAAIKAANR DLATPVMQPC 480
TALDSHKELN TSSKRALGAH LEAEPKSQRS AVQKPPSTGS APAIESVD 528 
Gene Ontology
 GO:0005829; C:cytosol; ISS:UniProtKB.
 GO:0031965; C:nuclear membrane; IDA:UniProtKB.
 GO:0046982; F:protein heterodimerization activity; IDA:UniProtKB.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0030500; P:regulation of bone mineralization; ISS:UniProtKB.
 GO:0010564; P:regulation of cell cycle process; IMP:UniProtKB.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR026183; Taxilin_fam. 
Pfam
 PF09728; Taxilin 
SMART
  
PROSITE
  
PRINTS