CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018673
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Fatty acyl-CoA reductase 1 
Protein Synonyms/Alias
 Male sterility domain-containing protein 2 
Gene Name
 Far1 
Gene Synonyms/Alias
 Mlstd2 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
443NYCMGTKKYVLNEEMubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Catalyzes the reduction of saturated fatty acyl-CoA with chain length C16 or C18 to fatty alcohols. 
Sequence Annotation
  
Keyword
 Alternative splicing; Complete proteome; Lipid biosynthesis; Lipid metabolism; Membrane; NADP; Oxidoreductase; Peroxisome; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 515 AA 
Protein Sequence
MVSIPEYYEG KNILLTGATG FLGKVLLEKL LRSCPRVNSV YVLVRQKAGQ TPQERVEEIL 60
SSKLFDRLRD ENPDFREKII AINSELTQPK LALSEEDKEI IIDSTNVIFH CAATVRFNEN 120
LRDAVQLNVI ATRQLILLAQ QMKNLEVFMH VSTAYAYCNR KHIDEVVYPP PVDPKKLIDS 180
LEWMDDGLVN DITPKLIGDR PNTYIYTKAL AEYVVQQEGA KLNVAIVRPS IVGASWKEPF 240
PGWIDNFNGP SGLFIAAGKG ILRTMRASNN ALADLVPVDV VVNTSLAAAW YSGVNRPRNI 300
MVYNCTTGST NPFHWGEVEY HVISTFKRNP LEQAFRRPNV NLTSNHLLYH YWIAVSHKAP 360
AFLYDIYLRM TGRSPRMMKT ITRLHKAMVF LEYFTSNSWV WNTDNVNMLM NQLNPEDKKT 420
FNIDVRQLHW AEYIENYCMG TKKYVLNEEM SGLPAARKHL NKLRNIRYGF NTILVILIWR 480
IFIARSQMAR NIWYFVVSLC YKFLSYFRAS STMRY 515 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005778; C:peroxisomal membrane; IEA:UniProtKB-SubCell.
 GO:0005777; C:peroxisome; IDA:MGI.
 GO:0080019; F:fatty-acyl-CoA reductase (alcohol-forming) activity; IEA:InterPro.
 GO:0050062; F:long-chain-fatty-acyl-CoA reductase activity; IDA:MGI.
 GO:0008611; P:ether lipid biosynthetic process; IEA:Compara.
 GO:0046474; P:glycerophospholipid biosynthetic process; IEA:Compara.
 GO:0035336; P:long-chain fatty-acyl-CoA metabolic process; IEA:Compara.
 GO:0010025; P:wax biosynthetic process; IDA:UniProtKB. 
Interpro
 IPR026055; FAR.
 IPR013120; Male_sterile_NAD-bd.
 IPR016040; NAD(P)-bd_dom. 
Pfam
 PF07993; NAD_binding_4
 PF03015; Sterile 
SMART
  
PROSITE
  
PRINTS