| Tag | Content |
|---|
| CPLM ID | CPLM-016519 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein NPAT |
Protein Synonyms/Alias | |
Gene Name | Npat |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 243 | PNAFAVEKQMVIENA | acetylation | [1] | | 999 | RNKLITGKQVNNLTN | acetylation | [1] |
|
Reference | [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways. Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y. Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [ PMID: 22826441] |
Functional Description | Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with MIZF. Also positively regulates the ATM, MIZF and PRKDC promoters. Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters (By similarity). Required for early embryonic development. |
Sequence Annotation | DOMAIN 3 35 LisH.
REGION 1 319 Interaction with MIZF (By similarity).
REGION 5 25 Required for activation of histone gene
REGION 121 145 Required for activation of histone gene
REGION 263 339 Mediates transcriptional activation (By
REGION 628 652 Required for acceleration of G1 phase (By
REGION 822 847 Required for acceleration of G1 phase (By
REGION 1033 1048 Required for acceleration of G1 phase (By
REGION 1223 1247 Required for acceleration of G1 phase (By
REGION 1319 1342 Required for acceleration of G1 phase (By
MOD_RES 771 771 Phosphoserine; by CDK2 (By similarity).
MOD_RES 773 773 Phosphoserine; by CDK2 (By similarity).
MOD_RES 1096 1096 Phosphoserine; by CDK2 (By similarity).
MOD_RES 1223 1223 N6-acetyllysine (By similarity).
MOD_RES 1264 1264 Phosphothreonine; by CDK2 (By
MOD_RES 1343 1343 Phosphothreonine; by CDK2 (By |
Keyword | Acetylation; Activator; Cell cycle; Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1420 AA |
Protein Sequence | MLLPSDVARL VLGYLQQENL TSTCQTFILE SSNLKEYAEH CTDEGFIPAC LLSLFGKNLT 60
TILNEYVAMK AKETSNDVPT IMSSLWKKLD HTLSQIRSMH SSPGFAAHQR ARTRNGIAEI 120
KRQRWLASQA APVSSELLVL PYASGQFTTS PLVATQAVKP TGPISTPVRS NIVVVNQSQP 180
QSTVTNTAGE SLNIIPGPQE RKTQTSLMSP GRRKSESQKK SLTSSGPHSS RNFQDPNAFA 240
VEKQMVIENA REKILSNKSL QEKLAENINK FLTSDSSVAQ VPKQTDSNPT EPETSIDELL 300
GLPSEIHMSE EAIQDILEQT ESDPAFQALF DLFDYGKTKN NKNMPQISSQ PMETNSNIVL 360
PEETNLTIKS SFETEESDGQ SGQPPFCTSY QNEDVLLNDL KSGNSHDVLP QESQENFSQI 420
SSNIQKKTFK TAIPAEQKCA LDITLESVSN LSDFNQRGSS AECNEHCSEL FASQIPTEAE 480
VAVGEKNSLS ADILSQSQYQ PDQPSVPVTS FVSLGGETND KNLVLSGKNS QLLSQSTPLT 540
TKPSKSQLCE NSNNIIKVKT NPQASESADS SETANRKTET NTVSPAAAQP QADCQDNSPL 600
QSKPPPGIGE SLGVNVTEKI EIHLEEPAPS DKQLSNDAAS VDLNPTESKT EPLQSASAQE 660
PEPPSVKDGD TIFLSLSEHN SCEEVALVLG EGNPVKNNNS LSSESGGSVG VSPETQNTDG 720
KTSNSTEVDA SSIVSLKIII SDDPFVSSDA ELNSAVSSIS GENLPTIILS SKSPAKNAEF 780
VTCLSSEETA SAVVSVEVGD SGSMEQNLLV LKPEEPMVNN TQNEDGIAFS ANVAPCVPKD 840
GGYIQLMPTT STAFGNSSNI LIATCMTDST ALGPTVSQSN VVVLPGSSAP MTAQPPQQQL 900
QTPPKSNSAF AVSQAVSPNF SQGSAIIIAS PVQPVLQGMV GMIPVSVVGQ NGNTFSTPPQ 960
QVLHMPLAAP VCNRSIAQLP IPQKSQKAQG LRNKLITGKQ VNNLTNLSSL SEACHTQRTE 1020
ASDKNIATEL GKKMEDTTIS LSGERVAPPS KPFESHRRVL CFDSTVSSVA NTQGSLYKMT 1080
SENKEKKEAS FSHLDSPILS STLKPPPNNA IKREREKTVP KILSKSETAS SRHTTVKEVQ 1140
SEKKVSPTEV ALESLHKATA NKENELCGDG ERPKNADTSK LPGGQQNGSL RNEKAIASLQ 1200
ELTKKQATPS NNKNATSVGG TVKDQKQEQS KPASSLIGAE ILQDVPIHSP ANRSADTDLP 1260
VPRTPGSGAG EKHKEEPSDS MKAPASRRCG EEGSMPRVMI PPVTADLPAC SPASETGSEN 1320
SVSMAAHTLM ILSRAAIART TATPLKDNTQ QFRTSSRSTT KKRKIEELDE CERNSRTSGK 1380
NLANSSVPMK KKKIKKKKLP SSFPAGMDVD KFLLSLHYDE 1420 |
Gene Ontology | GO:0015030; C:Cajal body; IEA:Compara. GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:Compara. GO:0003713; F:transcription coactivator activity; ISS:UniProtKB. GO:0003714; F:transcription corepressor activity; IEA:Compara. GO:0045893; P:positive regulation of transcription, DNA-dependent; IEA:Compara. GO:0000083; P:regulation of transcription involved in G1/S phase of mitotic cell cycle; IEA:Compara. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |