CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013150
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Testis-expressed sequence 10 protein 
Protein Synonyms/Alias
  
Gene Name
 Tex10 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
589QANKDLLKNLQAAALubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. 
Sequence Annotation
 REPEAT 99 137 HEAT.
 MOD_RES 29 29 Phosphothreonine (By similarity).  
Keyword
 Complete proteome; Cytoplasm; Membrane; Nucleus; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 928 AA 
Protein Sequence
MTKKRKRQDD FQKVKLKVGK KKPKLENATA TNFKTKAIHL PEQLKEDRTL PTNNRKLNIK 60
DLLSQMHHYS GGVKQSALLG LKDLLSQYPF IIDAHLSNIL SEVTAVFTDR DANVRLAAVQ 120
LLQFLAPKIR TEHISPFFPL VSAHLSSAMT HITEGIQEDS LKVLDILLEH YPALITGRSS 180
ILLKNFVELI SHQQLSKGLV NRDRSQSWIL SVNPNRRVTS QQWRLKVLAR LSKFLQALAD 240
GSSRLRESEG LQEQKETPHA TSNSIFINWK DHANDQQQIQ VYENGGSQPN VSSQFRLRCL 300
GTLGTVDEDL SSPENLKGFI EIIIPLLIEC WIEALPPQLA ASVGSGVERE PLQVMQQVLN 360
VISLLWKLSK QQDETHTLES WLRKNYLTDF KHHFMSHFPY ALKEITKQRK KDTNKSIKHC 420
TVLSNNVDHL LLNLTLSDIM VSLANASTLQ NDSSWIETIR KFVTETLKGG TRLNSKQLNR 480
LLGVSWRLIQ MQPNRDATEN LIKAVYTLYQ QRGLLLPVRT LLIKFFSKIY QKEELRSYRL 540
RYRSKVLSRW LAGLPLQLSY LGSRNPELST QLIDIIHTAA SQANKDLLKN LQAAALRIYD 600
PQEGAVVVLP AESQQRLVQL LYFLPTLPAD LLSQLSRCCI MGRLGSSLAV TLIGILYMRS 660
SFSGWSHSVN DCLMTDVDYL SFLFSTLTGF SKEELTWLQN LRGVPHVVQT SLSPVLLYLT 720
DLDQFLHHWD ITEAVCHSLL VIPARSQSFD IMQSAISKHL VGLTVIPDST AGCIFGVMCK 780
LLDHTCVVNE ALLPFLASCC YSLLYFLLTL EKGDAEHLKK RDKLWEVCVS ILALLPRVLR 840
LMLQSLRVNR ASPEELPVVG QLLRLLLQHV PLRSHMLTNA ILVQQIIKNI TTLKSGSVQE 900
QWLTDLHYCF SVYISGHPQG PSILNALY 928 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0071339; C:MLL1 complex; ISS:UniProtKB.
 GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
 GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell. 
Interpro
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR021133; HEAT_type_2.
 IPR024679; IPI1/TEX10. 
Pfam
 PF12333; Ipi1_N 
SMART
  
PROSITE
 PS50077; HEAT_REPEAT 
PRINTS