UniProt Accession

 SLYA_ECOLI; P0A8W2; P55740 

Genbank Protein ID

 AJ010965; Y11194; U00096; AP009048 

Genbank Nucleotide ID

 CAA09442.1; CAA72078.1; AAC74714.2; BAA15403.2 

Protein Name

 Transcriptional regulator SlyA 

Protein Synonyms/Alias

  

Gene Name

 slyA 

Gene Synonyms/Alias

 b1642; JW5267 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
25	ALIDHRLKPLELTQT	acetylation	[1]
73	TLDQLEEKGLISRQT	acetylation	[1]
95	KRIKLTEKAEPLISE	acetylation	[1]
109	EMEAVINKTRAEILH	acetylation	[1]
143	NIIELQAKG******	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Transcription regulator that can specifically activate or repress expression of target genes. Activates expression of genes such as molecular chaperones (groL, groS, dnaK, grpE, and cbpA), proteins involved in acid resistance (hdeA, hdeB, and gadA), the starvation lipoprotein slp, virulence protein hlyE/clyA. Represses expression of genes involved in the histidine biosynthetic pathway such as hisA, hisB, hisD, hisF and hisG. Required for the activation of virulence genes. 

Sequence Annotation

 DOMAIN 2 135 HTH marR-type.
 DNA_BIND 49 72 H-T-H motif (By similarity).  

Keyword

 Activator; Complete proteome; DNA-binding; Reference proteome; Repressor; Transcription; Transcription regulation; Virulence. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 144 AA 

Protein Sequence

Gene Ontology

 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0003677; F:DNA binding; IEA:HAMAP.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IMP:EcoliWiki.
 GO:0009405; P:pathogenesis; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR000835; Tscrpt_reg_HTH_MarR-typ.
 IPR023187; Tscrpt_reg_MarR-type_CS.
 IPR023071; Tscrpt_reg_SlyA.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF01047; MarR 

SMART

 SM00347; HTH_MARR 

PROSITE

 PS01117; HTH_MARR_1
 PS50995; HTH_MARR_2 

PRINTS

 PR00598; HTHMARR.