CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042449
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Probable E3 ubiquitin-protein ligase HERC4 
Protein Synonyms/Alias
  
Gene Name
 HERC4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
215IFGWGRNKFGQLGLNubiquitination[1, 2, 3]
234RYVPNLLKSLRSQKIubiquitination[2, 3, 4]
240LKSLRSQKIVYICCGubiquitination[2, 4]
333TGSTSNRKSPFTVKGubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 399 AA 
Protein Sequence
XGNASFGQLG LGGIDEEIVL EPRKSDFFIN KRVRDVGCGL RHTVFVLDDG TVYTCGCNDL 60
GQLGHEKSRK KPEQVVALDA QNIVAVSCGE AHTLALNDKG QVYAWGLDSD GQLGLVGSEE 120
CIRVPRNIKS LSDIQIVQVA CGYYHSLALS KASEVFCWGQ NKYGQLGLGT DCKKQTSPQL 180
LKSLLGIPFM QVAAGGAHSF VLTLSGAIFG WGRNKFGQLG LNDENDRYVP NLLKSLRSQK 240
IVYICCGEDH TAALTKEGGV FTFGAGGYGQ LGHNSTSHEI NPRKVFELMG SIVTEIACGR 300
QHTSAFVPSS GRIYSFGLGG NGQLGTGSTS NRKSPFTVKG NWYPYNGQCL PDIEARSCHV 360
VQAGLELLGS SDPPTLASQS AGITVNEHQC LLPPQKRTQ 399 
Gene Ontology
  
Interpro
 IPR009091; RCC1/BLIP-II.
 IPR000408; Reg_chr_condens. 
Pfam
 PF00415; RCC1 
SMART
  
PROSITE
 PS00626; RCC1_2
 PS50012; RCC1_3 
PRINTS
 PR00633; RCCNDNSATION.