CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031807
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Elongation factor 2, putative 
Protein Synonyms/Alias
 Elongation factor, putative 
Gene Name
 TGME49_005470, TGVEG_043820 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Toxoplasma gondii 
NCBI Taxa ID
 5811 
Lysine Modification
Position
Peptide
Type
References
226FSKIYAKKFDVPKEKacetylation[1]
247GNNFYNAKEKKWTKTacetylation[2]
340PSPFAAQKYRVENLYacetylation[2]
413PRYVPGEKTDLYIKSacetylation[1]
419EKTDLYIKSIQRTVIacetylation[1, 2]
Reference
 [1] Protein intrinsic disorder in the acetylome of intracellular and extracellular Toxoplasma gondii.
 Xue B, Jeffers V, Sullivan WJ, Uversky VN.
 Mol Biosyst. 2013 Apr 5;9(4):645-57. [PMID: 23403842]
 [2] Lysine acetylation is widespread on proteins of diverse function and localization in the protozoan parasite Toxoplasma gondii.
 Jeffers V, Sullivan WJ Jr.
 Eukaryot Cell. 2012 Jun;11(6):735-42. [PMID: 22544907] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Elongation factor; GTP-binding; Nucleotide-binding; Protein biosynthesis; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 832 AA 
Protein Sequence
MVNFSVEQMR EIMGNPKNIR NMSVIAHVDH GKSTLTDSLV SKAGIISAKA AGDARFTDTR 60
ADEQERCITI KSTGISMYFE HDMEDGKGAQ PYLINLIDSP GHVDFSSEVT AALRVTDGAL 120
VVVDTIEGVC VQTETVLRQA LAERIRPVLH VNKVDRALLE LQMDGEEIYQ TFSRTIENVN 180
VIISTYNDEL MGDVQVYPEK GTVSFGSGLH GWAFTVERFS KIYAKKFDVP KEKMMERLWG 240
NNFYNAKEKK WTKTQSENTR RAFCQFIMDP ICTLFTSIMN DEKEKYTKML GSLGIELKGD 300
DRDLTGKALL KRVMQLWLPA GDTLLEMVVR HLPSPFAAQK YRVENLYEGP MDDEAAQGIR 360
NCDPNAPLMM YVSKMVPTSD KGRFYAFGRV FSGTVATGQK VRIQGPRYVP GEKTDLYIKS 420
IQRTVIMMGK YVEHVQDVPC GNTCCLVGVD QYLLKSGTLT TLDTAHNIAD MKYSVSPVVR 480
VAVKPKDNKE LPKLVEGLKK LSKSDPLVVC TTEESGEHII AGCGELHVEI CLKDLRDEYA 540
QIDFTVSDPV VSYRETVSAP SHMTCLSKSP NKHNRLYMVA EPFPDGLADA IEAGQVNARD 600
DPKERANALA EKFDFDKNAA LKIWCFGPET TGANMLIDTT QGVQYLNEIK EHCNSAFQWA 660
SKEGVLCEEN MRGIRFNLTD VTMHADAIHR GAGQIMPTCR RVLYACQLAS APRLQEPMFL 720
VDITCPQDAV GGIYSTLNTR RGHVFHEEQR SGTPLVEIKA YLPVAESFGF TTALRAATSG 780
QAFPQCVFDH WSTLNGDPLE KGSKMEELVH NIRTRKNLKP EIPPFENYYD KL 832 
Gene Ontology
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; IEA:InterPro.
 GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
 GO:0006184; P:GTP catabolic process; IEA:GOC. 
Interpro
 IPR000795; EF_GTP-bd_dom.
 IPR009022; EFG_III-V.
 IPR000640; EFG_V.
 IPR027417; P-loop_NTPase.
 IPR020568; Ribosomal_S5_D2-typ_fold.
 IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
 IPR005225; Small_GTP-bd_dom.
 IPR005517; Transl_elong_EFG/EF2_IV.
 IPR004161; Transl_elong_EFTu/EF1A_2.
 IPR009000; Transl_elong_init/rib_B-barrel. 
Pfam
 PF00679; EFG_C
 PF03764; EFG_IV
 PF00009; GTP_EFTU
 PF03144; GTP_EFTU_D2 
SMART
 SM00838; EFG_C
 SM00889; EFG_IV 
PROSITE
 PS00301; EFACTOR_GTP 
PRINTS
 PR00315; ELONGATNFCT.