UniProt Accession

 ANM1_RAT; Q63009 

Genbank Protein ID

 U60882; BC078815 

Genbank Nucleotide ID

 AAC52622.1; AAH78815.1 

Protein Name

 Protein arginine N-methyltransferase 1 

Protein Synonyms/Alias

 Histone-arginine N-methyltransferase PRMT1 

Gene Name

 Prmt1 

Gene Synonyms/Alias

 Hrmt1l2 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
116	VKIVKANKLDHVVTI	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15 and EWS. Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. 

Sequence Annotation

 ACT_SITE 144 144 By similarity.
 ACT_SITE 153 153 By similarity.
 BINDING 45 45 S-adenosyl-L-methionine.
 BINDING 54 54 S-adenosyl-L-methionine.
 BINDING 78 78 S-adenosyl-L-methionine; via carbonyl
 BINDING 100 100 S-adenosyl-L-methionine.
 BINDING 129 129 S-adenosyl-L-methionine.  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Methyltransferase; Nucleus; Reference proteome; S-adenosyl-L-methionine; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 353 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:RGD.
 GO:0043234; C:protein complex; IDA:RGD.
 GO:0016275; F:[cytochrome c]-arginine N-methyltransferase activity; IDA:MGI.
 GO:0044020; F:histone methyltransferase activity (H4-R3 specific); ISS:UniProtKB.
 GO:0035242; F:protein-arginine omega-N asymmetric methyltransferase activity; IDA:MGI.
 GO:0035241; F:protein-arginine omega-N monomethyltransferase activity; IDA:MGI.
 GO:0030519; F:snoRNP binding; IDA:RGD.
 GO:0001701; P:in utero embryonic development; IEA:Compara.
 GO:0045653; P:negative regulation of megakaryocyte differentiation; ISS:UniProtKB.
 GO:0031175; P:neuron projection development; IEA:Compara. 

Interpro

 IPR025799; Arg_MeTrfase.
 IPR025714; Methyltranfer_dom. 

Pfam

 PF13847; Methyltransf_31 

SMART

  

PROSITE

  

PRINTS