UniProt Accession

 YAP4_YEAST; P40917; D6W294 

Genbank Protein ID

 U16780; X87331; Z74936; BK006948 

Genbank Nucleotide ID

 AAA52752.1; CAA60744.1; CAA99218.1; DAA10810.1 

Protein Name

 AP-1-like transcription factor YAP4 

Protein Synonyms/Alias

 Chromosome instability protein 5; Transcription activator CIN5 

Gene Name

 CIN5 

Gene Synonyms/Alias

 HAL6; SDS15; YAP4; YOR028C; OR26.18 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
194	NSTPATRKNSATTNL	ubiquitination	[1]

Reference

 [1] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047] 

Functional Description

 Transcription activator involved in the regulation of genes expressed in response to environmental changes and metabolic requirements. According to genome-wide promoter binding and gene expression studies it regulates, among others, genes involved in ribosome biogenesis, and protein synthesis. It may also be involved in pleiotropic drug resistance. When overexpressed it confers increased resistance to cisplatin, the DNA-alkylating agents methylmethanosulfonate, and mitomycin C, the antimalarial drugs quinidine, mefloquine, and chloroquine, and increases cellular tolerance to sodium and lithium. Preferentially binds 5'- TTACTAA-3'. 

Sequence Annotation

 DOMAIN 237 295 bZIP.
 REGION 239 260 Basic motif (By similarity).
 REGION 262 271 Leucine-zipper (By similarity).
 MOD_RES 85 85 Phosphoserine.
 MOD_RES 89 89 Phosphoserine.
 MOD_RES 196 196 Phosphoserine.  

Keyword

 Activator; Complete proteome; Cytoplasm; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 295 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0070491; F:repressing transcription factor binding; IDA:SGD.
 GO:0043565; F:sequence-specific DNA binding; IDA:SGD.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0042538; P:hyperosmotic salinity response; IMP:SGD.
 GO:0006357; P:regulation of transcription from RNA polymerase II promoter; ISA:SGD.
 GO:0042493; P:response to drug; IMP:SGD.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR004827; bZIP. 

Pfam

 PF00170; bZIP_1 

SMART

 SM00338; BRLZ 

PROSITE

 PS50217; BZIP
 PS00036; BZIP_BASIC 

PRINTS