CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030010
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Peroxiredoxin-1 
Protein Synonyms/Alias
  
Gene Name
 Prdx1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
7*MSSGNAKIGYPAPNacetylation[1]
7*MSSGNAKIGYPAPNsuccinylation[1]
7*MSSGNAKIGYPAPNubiquitination[2]
16GYPAPNFKATAVMPDacetylation[3, 4]
16GYPAPNFKATAVMPDubiquitination[2]
27VMPDGQFKDISLSEYacetylation[1, 3, 5]
27VMPDGQFKDISLSEYsuccinylation[1]
27VMPDGQFKDISLSEYubiquitination[2]
35DISLSEYKGKYVVFFacetylation[1, 3, 4, 5, 6]
35DISLSEYKGKYVVFFsuccinylation[1]
35DISLSEYKGKYVVFFubiquitination[2]
68DRADEFKKLNCQVIGacetylation[5]
93AWINTPKKQGGLGPMacetylation[1]
93AWINTPKKQGGLGPMsuccinylation[1]
93AWINTPKKQGGLGPMubiquitination[2]
109IPLISDPKRTIAQDYacetylation[4, 5]
109IPLISDPKRTIAQDYubiquitination[2]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [4] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [5] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [6] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 123 AA 
Protein Sequence
MSSGNAKIGY PAPNFKATAV MPDGQFKDIS LSEYKGKYVV FFFYPLDFTF VCPTEIIAFS 60
DRADEFKKLN CQVIGASVDS HFCHLAWINT PKKQGGLGPM NIPLISDPKR TIAQDYGVLK 120
ADE 123 
Gene Ontology
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005759; C:mitochondrial matrix; IEA:Compara.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005719; C:nuclear euchromatin; IEA:Compara.
 GO:0005730; C:nucleolus; IEA:Compara.
 GO:0005782; C:peroxisomal matrix; IEA:Compara.
 GO:0020037; F:heme binding; IEA:Compara.
 GO:0008379; F:thioredoxin peroxidase activity; IEA:Compara.
 GO:0008283; P:cell proliferation; IMP:MGI.
 GO:0034101; P:erythrocyte homeostasis; IMP:MGI.
 GO:0042744; P:hydrogen peroxide catabolic process; IEA:Compara.
 GO:0042267; P:natural killer cell mediated cytotoxicity; IMP:MGI.
 GO:0042345; P:regulation of NF-kappaB import into nucleus; IMP:MGI.
 GO:0032872; P:regulation of stress-activated MAPK cascade; IMP:MGI.
 GO:0019430; P:removal of superoxide radicals; IMP:MGI. 
Interpro
 IPR000866; AhpC/TSA.
 IPR012336; Thioredoxin-like_fold. 
Pfam
 PF00578; AhpC-TSA 
SMART
  
PROSITE
 PS51352; THIOREDOXIN_2 
PRINTS