CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006971
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ribose-phosphate pyrophosphokinase 3 
Protein Synonyms/Alias
 Phosphoribosyl pyrophosphate synthase 3 
Gene Name
 PRS3 
Gene Synonyms/Alias
 PRPS3; YHL011C 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
23GLAELVAKRLGLQLTubiquitination[1]
267IENINNSKLDRVVCTubiquitination[1]
316ESISYLFKNYPL***ubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis. Active in heteromultimeric complexes with other 5-phosphoribose 1- diphosphate synthases (PRS2, PRS3, PRS4 and PRS5). 
Sequence Annotation
 METAL 131 131 Magnesium (Potential).
 METAL 133 133 Magnesium (Potential).
 METAL 142 142 Magnesium (Potential).
 METAL 146 146 Magnesium (Potential).  
Keyword
 ATP-binding; Complete proteome; Cytoplasm; Kinase; Magnesium; Metal-binding; Nucleotide biosynthesis; Nucleotide-binding; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 320 AA 
Protein Sequence
MPTNSIKLLA PDVHRGLAEL VAKRLGLQLT SSKLKRDPTG EVSFSIGESV RDQDIFIITQ 60
IGSGVVNDRV LELLIMINAS KTASARRITA IIPNFPYARQ DRKDKSRAPI TAKLMADMLT 120
TAGCDHVITM DLHASQIQGF FDVPVDNLYA EPSVVRYIKE NVNYMDSIII SPDAGGAKRA 180
ATLADRLDLN FALIHKERAR ANEVSRMVLV GDVTDKICII VDDMADTCGT LAKAAEILLE 240
NRAKSVIAIV THGVLSGRAI ENINNSKLDR VVCTNTVPFE EKIKKCPKLA VIDISSVLAE 300
SIRRLHNGES ISYLFKNYPL 320 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
 GO:0000287; F:magnesium ion binding; IEA:InterPro.
 GO:0004749; F:ribose phosphate diphosphokinase activity; IEA:EC.
 GO:0006015; P:5-phosphoribose 1-diphosphate biosynthetic process; IMP:SGD.
 GO:0031505; P:fungal-type cell wall organization; IPI:SGD.
 GO:0009165; P:nucleotide biosynthetic process; IEA:UniProtKB-KW.
 GO:0008361; P:regulation of cell size; IMP:SGD.
 GO:0009156; P:ribonucleoside monophosphate biosynthetic process; IEA:InterPro. 
Interpro
 IPR000842; PRib_PP_synth_CS.
 IPR000836; PRibTrfase_dom.
 IPR005946; Rib-P_diPkinase. 
Pfam
 PF00156; Pribosyltran 
SMART
  
PROSITE
 PS00114; PRPP_SYNTHASE 
PRINTS