UniProt Accession

 EIF3M_MOUSE; Q99JX4; Q3TI04; Q5EBI5 

Genbank Protein ID

 AK077480; AK084738; AK146222; AK168066; AL606494; BC005598; BC089568; BC103795; BC116787; BC116789 

Genbank Nucleotide ID

 BAC36821.1; BAC39270.1; BAE26990.1; BAE40042.1; CAM17236.1; AAH05598.1; AAH89568.1; AAI03796.1; AAI16788.1; AAI16790.1 

Protein Name

 Eukaryotic translation initiation factor 3 subunit M 

Protein Synonyms/Alias

 eIF3m; PCI domain-containing protein 1 

Gene Name

 Eif3m 

Gene Synonyms/Alias

 Pcid1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
227	FDHLLTLKPVKFLEG	ubiquitination	[1]
254	AKLASYVKFYQNNKD	ubiquitination	[1]
260	VKFYQNNKDFIDSLG	ubiquitination	[1]
344	STHRTFGKQQWQQLY	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (By similarity). 

Sequence Annotation

 DOMAIN 235 336 PCI.
 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 2 2 Phosphoserine (By similarity).
 MOD_RES 254 254 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Initiation factor; Phosphoprotein; Protein biosynthesis; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 374 AA 

Protein Sequence

Gene Ontology

 GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:HAMAP.
 GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:HAMAP.
 GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:HAMAP.
 GO:0003743; F:translation initiation factor activity; IEA:HAMAP.
 GO:0001731; P:formation of translation preinitiation complex; IEA:HAMAP.
 GO:0006446; P:regulation of translational initiation; IEA:HAMAP. 

Interpro

 IPR027528; eIF3m.
 IPR000717; PCI_dom.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF01399; PCI 

SMART

 SM00088; PINT 

PROSITE

  

PRINTS