Tag | Content |
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CPLM ID | CPLM-023537 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Sodium/potassium-transporting ATPase subunit alpha-4 |
Protein Synonyms/Alias | Na(+)/K(+) ATPase alpha-4 subunit; Sodium pump subunit alpha-4 |
Gene Name | Atp1a4 |
Gene Synonyms/Alias | Atp1al2 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
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172 | SKIMESFKNMVPQQA | ubiquitination | [1] |
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Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Plays a role in sperm motility (By similarity). |
Sequence Annotation | REGION 91 93 Interaction with phosphoinositide-3 ACT_SITE 386 386 4-aspartylphosphate intermediate (By METAL 726 726 Magnesium (By similarity). METAL 730 730 Magnesium (By similarity). MOD_RES 952 952 Phosphoserine; by PKA (By similarity). |
Keyword | ATP-binding; Cell membrane; Complete proteome; Direct protein sequencing; Hydrolase; Ion transport; Magnesium; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Potassium; Potassium transport; Reference proteome; Sodium; Sodium transport; Sodium/potassium transport; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1032 AA |
Protein Sequence | MEPGKEKEVE APGELNQKPR PSTRSSTTNR QPKMKRRKKD LEELKKEVVM DDHKLTLDEL 60 SAKYSVDLTK GLSILEAQDI LFQNGPNVLT PPPTTPEWVK FCRQLFGGFS LLLWTGACLC 120 FLAYGIHVNY YKENANKDNL YLGIVLSAVV IITGCFSYYQ EAKSSKIMES FKNMVPQQAL 180 VIRDGEKMQI NVRDVVLGDL VEVKGGDQIP ADIRVISAQG CKVDNSSLTG ESEPQSRCPD 240 CTHENPLETR NIIFFSTNCV EGTARGIVIA TGDYTVMGRI ASLTSGLQMG KTPIATEIEH 300 FIHLITAVAV FLGVSFFWLS IILGYTWLDA VIFLIGIIVA NVPEGLLATV TVCLTLTAKR 360 MARKNCLVKN LEAVETLGST STICSDKTGT LTQNRMTVAH LWFDKTVYEA DTSEEQTTGK 420 TFPKSSDTWF YLARIAGLCN RADFKPHQES VPIAKRATTG DASESALLKF IEQSYNPVSE 480 MRQKNPKVAE IPFNSTNKYQ MSIHLLEDNS EAHVLLMKGA PERIFDFCSS FLLNGQEYPM 540 DEEMKMDFQN AYIELGGLGE RVLGFCFLNL PSNFSKGFQF NTDELNFPME NLCFAGLISM 600 IDPPRTAVPD AVSKCRSAGI KVIMVTGDHP ITAKAIAKSV GIISEGNDTA EDIAARLNIP 660 ISQVNNKSVK AIVVHGSELK DMESQQLDDI LKSYKEIVFA RTSPQQKLII VEGCQRLGAI 720 VAVTGDGVND SPALKKADIG IAMGITGSDV SKQAADMILL DDNFASIVTG VEEGRLIFDN 780 LKKSIAYTLT SNIPEITPFL LFIILSIPLP LGTITILCID LGTDMVPAIS LAYESPESDI 840 MKRLPRNPKT DNLVNNRLIG MAYGQIGMIQ ALAGFFTYFV ILAENGFKPL DLLGIRLYWD 900 DTQLNDLEDS YGQQWTYEQR KVVEFTCQTA FFISIVIVQW ADLIICKTRR NSLFKQGMKN 960 KILIFGLLEE TVLAAFLSYV PGMDVSLRMY PLKINWWFCA LPYSVLIFVY DEIRKLIIRR 1020 RPGGWLEKET YY 1032 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0005391; F:sodium:potassium-exchanging ATPase activity; IMP:MGI. GO:0006754; P:ATP biosynthetic process; IEA:InterPro. GO:0009566; P:fertilization; IMP:MGI. GO:0030641; P:regulation of cellular pH; ISS:UniProtKB. GO:0042391; P:regulation of membrane potential; IMP:MGI. GO:0030317; P:sperm motility; ISS:UniProtKB. GO:0007283; P:spermatogenesis; IMP:MGI. |
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