UniProt Accession

 DHB8_HUMAN; Q92506; A6NLX7; Q5STP7; Q9UIQ1 

Genbank Protein ID

 BT007239; AL031228; AL662824; AL713971; AL713971; AL662824; AL645940; AL844527; CR759786; CR759733; CR847841; CH471081; BC008185; D82061 

Genbank Nucleotide ID

 AAP35903.1; CAC38444.1; CAI17616.1; CAI17616.1; CAI17657.1; CAI17657.1; CAI18068.1; CAI41840.1; CAQ08245.1; CAQ10302.1; CAQ10313.1; EAX03682.1; AAH08185.1; BAA11529.1 

Protein Name

 Estradiol 17-beta-dehydrogenase 8 

Protein Synonyms/Alias

 17-beta-hydroxysteroid dehydrogenase 8; 17-beta-HSD 8; 3-oxoacyl-[acyl-carrier-protein] reductase; Protein Ke6; Ke-6; Really interesting new gene 2 protein; Testosterone 17-beta-dehydrogenase 8 

Gene Name

 HSD17B8 

Gene Synonyms/Alias

 FABGL; HKE6; RING2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
173	QTNYAASKAGVIGLT	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. Has very low activity towards testosterone. The heteroteramer with CBR4 has NADH-dependent 3- ketoacyl-acyl carrier protein reductase activity. May play a role in biosynthesis of fatty acids in mitochondria. 

Sequence Annotation

 NP_BIND 15 23 NAD.
 NP_BIND 42 43 NAD.
 NP_BIND 74 76 NAD.
 NP_BIND 169 173 NAD.
 NP_BIND 202 204 NAD.
 ACT_SITE 169 169 Proton acceptor (By similarity).
 BINDING 156 156 Substrate (By similarity).  

Keyword

 3D-structure; Complete proteome; Fatty acid biosynthesis; Fatty acid metabolism; Lipid biosynthesis; Lipid metabolism; Mitochondrion; NAD; Oxidoreductase; Polymorphism; Reference proteome; Steroid biosynthesis. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 261 AA 

Protein Sequence

Gene Ontology

 GO:0005740; C:mitochondrial envelope; IEA:Compara.
 GO:0005759; C:mitochondrial matrix; IDA:UniProtKB.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IDA:UniProtKB.
 GO:0004303; F:estradiol 17-beta-dehydrogenase activity; IDA:UniProtKB.
 GO:0050327; F:testosterone 17-beta-dehydrogenase (NAD+) activity; IEA:Compara.
 GO:0047035; F:testosterone dehydrogenase (NAD+) activity; IEA:EC.
 GO:0008209; P:androgen metabolic process; IEA:Compara.
 GO:0006703; P:estrogen biosynthetic process; IDA:UniProtKB.
 GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniPathway. 

Interpro

 IPR002198; DH_sc/Rdtase_SDR.
 IPR002347; Glc/ribitol_DH.
 IPR016040; NAD(P)-bd_dom.
 IPR020904; Sc_DH/Rdtase_CS. 

Pfam

 PF00106; adh_short 

SMART

  

PROSITE

 PS00061; ADH_SHORT 

PRINTS

 PR00081; GDHRDH.
 PR00080; SDRFAMILY.