| Tag | Content |
|---|
| CPLM ID | CPLM-023667 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Serine/threonine-protein kinase SIK3 |
Protein Synonyms/Alias | Salt-inducible kinase 3; SIK-3; Serine/threonine-protein kinase QSK |
Gene Name | SIK3 |
Gene Synonyms/Alias | KIAA0999; QSK; L19 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 41 | VAIKIIDKTQLDEEN | ubiquitination | [1] | | 50 | QLDEENLKKIFREVQ | ubiquitination | [1] | | 132 | NIVHRDLKAENLLLD | ubiquitination | [1] |
|
Reference | [1] Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Mol Cell. 2011 Oct 21;44(2):325-40. [ PMID: 21906983] |
Functional Description | |
Sequence Annotation | DOMAIN 8 259 Protein kinase.
DOMAIN 286 326 UBA.
NP_BIND 14 22 ATP (By similarity).
ACT_SITE 130 130 Proton acceptor (By similarity).
BINDING 37 37 ATP (By similarity).
MOD_RES 13 13 Phosphothreonine.
MOD_RES 163 163 Phosphothreonine; by LKB1.
MOD_RES 493 493 Phosphoserine.
MOD_RES 533 533 Phosphoserine (By similarity).
MOD_RES 534 534 Phosphoserine (By similarity).
MOD_RES 568 568 Phosphoserine.
MOD_RES 808 808 Phosphoserine. |
Keyword | Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Kinase; Magnesium; Metal-binding; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1263 AA |
Protein Sequence | MPARIGYYEI DRTIGKGNFA VVKRATHLVT KAKVAIKIID KTQLDEENLK KIFREVQIMK 60
MLCHPHIIRL YQVMETERMI YLVTEYASGG EIFDHLVAHG RMAEKEARRK FKQIVTAVYF 120
CHCRNIVHRD LKAENLLLDA NLNIKIADFG FSNLFTPGQL LKTWCGSPPY AAPELFEGKE 180
YDGPKVDIWS LGVVLYVLVC GALPFDGSTL QNLRARVLSG KFRIPFFMST ECEHLIRHML 240
VLDPNKRLSM EQICKHKWMK LGDADPNFDR LIAECQQLKE ERQVDPLNED VLLAMEDMGL 300
DKEQTLQSLR SDAYDHYSAI YSLLCDRHKR HKTLRLGALP SMPRALAFQA PVNIQAEQAG 360
TAMNISVPQV QLINPENQIV EPDGTLNLDS DEGEEPSPEA LVRYLSMRRH TVGVADPRTE 420
VMEDLQKLLP GFPGVNPQAP FLQVAPNVNF MHNLLPMQNL QPTGQLEYKE QSLLQPPTLQ 480
LLNGMGPLGR RASDGGANIQ LHAQQLLKRP RGPSPLVTMT PAVPAVTPVD EESSDGEPDQ 540
EAVQSSTYKD SNTLHLPTER FSPVRRFSDG AASIQAFKAH LEKMGNNSSI KQLQQECEQL 600
QKMYGGQIDE RTLEKTQQQH MLYQQEQHHQ ILQQQIQDSI CPPQPSPPLQ AACENQPALL 660
THQLQRLRIQ PSSPPPNHPN NHLFRQPSNS PPPMSSAMIQ PHGAASSSQF QGLPSRSAIF 720
QQQPENCSSP PNVALTCLGM QQPAQSQQVT IQVQEPVDML SNMPGTAAGS SGRGISISPS 780
AGQMQMQHRT NLMATLSYGH RPLSKQLSAD SAEAHSLNVN RFSPANYDQA HLHPHLFSDQ 840
SRGSPSSYSP STGVGFSPTQ ALKVPPLDQF PTFPPSAHQQ PPHYTTSALQ QALLSPTPPD 900
YTRHQQVPHI LQGLLSPRHS LTGHSDIRLP PTEFAQLIKR QQQQRQQQQQ QQQQQEYQEL 960
FRHMNQGDAG SLAPSLGGQS MTERQALSYQ NADSYHHHTS PQHLLQIRAQ ECVSQASSPT 1020
PPHGYAHQPA LMHSESMEED CSCEGAKDGF QDSKSSSTLT KGCHDSPLLL STGGPGDPES 1080
LLGTVSHAQE LGIHPYGHQP TAAFSKNKVP SREPVIGNCM DRSSPGQAVE LPDHNGLGYP 1140
ARPSVHEHHR PRALQRHHTI QNSDDAYVQL DNLPGMSLVA GKALSSARMS DAVLSQSSLM 1200
GSQQFQDGEN EECGASLGGH EHPDLSDGSQ HLNSSCYPST CITDILLSYK HPEVSFSMEQ 1260
AGV 1263 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005524; F:ATP binding; IDA:UniProtKB. GO:0000287; F:magnesium ion binding; IDA:UniProtKB. GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |