UniProt Accession

 MTCU1_YEAST; P0CX80; D3DL02; P07215 

Genbank Protein ID

 K02204; U00061; AY558517; BK006934 

Genbank Nucleotide ID

 AAA34541.1; AAB68382.1; AAS56843.1; DAA06748.1 

Protein Name

 Copper metallothionein 1-1 

Protein Synonyms/Alias

 Cu-MT; Cu-metallothionein; Copper chelatin; Copper thionein 

Gene Name

 CUP1-1 

Gene Synonyms/Alias

 MTH1; YHR053C 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
30	KNNEQCQKSCSCPTG	ubiquitination	[1, 2]
43	TGCNSDDKCPCGNKS	ubiquitination	[1, 2]
49	DKCPCGNKSEETKKS	ubiquitination	[1]

Reference

 [1] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Protects the cell against copper toxicity by tightly chelating copper ions. May also act as a depository for copper designated for the effective transfer into the apo forms of copper proteins. 

Sequence Annotation

 METAL 15 15 Copper 1.
 METAL 15 15 Copper 2.
 METAL 17 17 Copper 1.
 METAL 17 17 Copper 3.
 METAL 19 19 Copper 4.
 METAL 19 19 Copper 5.
 METAL 22 22 Copper 3.
 METAL 22 22 Copper 4.
 METAL 22 22 Copper 6.
 METAL 28 28 Copper 2.
 METAL 28 28 Copper 6.
 METAL 32 32 Copper 1.
 METAL 32 32 Copper 7.
 METAL 34 34 Copper 3.
 METAL 34 34 Copper 7.
 METAL 34 34 Copper 8.
 METAL 38 38 Copper 5.
 METAL 38 38 Copper 8.
 METAL 44 44 Copper 4.
 METAL 44 44 Copper 8.
 METAL 46 46 Copper 6.
 METAL 46 46 Copper 7.  

Keyword

 3D-structure; Complete proteome; Copper; Direct protein sequencing; Metal-binding; Metal-thiolate cluster; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 61 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:SGD.
 GO:0046870; F:cadmium ion binding; IDA:SGD.
 GO:0005507; F:copper ion binding; IDA:SGD.
 GO:0004784; F:superoxide dismutase activity; IMP:SGD.
 GO:0071585; P:detoxification of cadmium ion; IMP:SGD.
 GO:0010273; P:detoxification of copper ion; IMP:SGD.
 GO:0019430; P:removal of superoxide radicals; IDA:SGD. 

Interpro

 IPR017854; Metalthion_dom.
 IPR022710; Metalthion_dom_yeast. 

Pfam

 PF11403; Yeast_MT 

SMART

  

PROSITE

  

PRINTS