CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000601
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Bone morphogenetic protein receptor type-2 
Protein Synonyms/Alias
 BMP type-2 receptor; BMPR-2; BRK-3; Bone morphogenetic protein receptor type II; BMP type II receptor; BMPR-II 
Gene Name
 Bmpr2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
180RMLTGDRKQGLHSMNubiquitination[1]
512MMIWERNKSVSPTVNubiquitination[1]
782NKHKSNLKQVETGVAubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP-7, BMP-2 and, less efficiently, BMP-4. Binding is weak but enhanced by the presence of type I receptors for BMPs. 
Sequence Annotation
 DOMAIN 203 504 Protein kinase.
 NP_BIND 209 217 ATP (By similarity).
 NP_BIND 280 282 ATP (By similarity).
 NP_BIND 337 338 ATP (By similarity).
 ACT_SITE 333 333 Proton acceptor (By similarity).
 BINDING 230 230 ATP (By similarity).
 BINDING 351 351 ATP (By similarity).
 MOD_RES 379 379 Phosphothreonine (By similarity).
 MOD_RES 586 586 Phosphoserine (By similarity).
 CARBOHYD 55 55 N-linked (GlcNAc...) (Potential).
 CARBOHYD 110 110 N-linked (GlcNAc...) (Potential).
 CARBOHYD 126 126 N-linked (GlcNAc...) (Potential).
 DISULFID 34 66 By similarity.
 DISULFID 94 117 By similarity.  
Keyword
 ATP-binding; Complete proteome; Disulfide bond; Glycoprotein; Kinase; Magnesium; Manganese; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Serine/threonine-protein kinase; Signal; Transferase; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1038 AA 
Protein Sequence
MTSSLHRPFR VPWLLWAVLL VSTTAASQNQ ERLCAFKDPY QQDLGIGESR ISHENGTILC 60
SKGSTCYGLW EKSKGDINLV KQGCWSHIGD PQECHYEECV VTTTPPSIQN GTYRFCCCST 120
DLCNVNFTEN FPPPDTTPLS PPHSFNRDET IIIALASVSV LAVLIVALCF GYRMLTGDRK 180
QGLHSMNMME AAAAEPSLDL DNLKLLELIG RGRYGAVYKG SLDERPVAVK VFSFANRQNF 240
INEKNIYRVP LMEHDNIARF IVGDERLTAD GRMEYLLVME YYPNGSLCKY LSLHTSDWVS 300
SCRLAHSVTR GLAYLHTELP RGDHYKPAIS HRDLNSRNVL VKNDGACVIS DFGLSMRLTG 360
NRLVRPGEED NAAISEVGTI RYMAPEVLEG AVNLRDCESA LKQVDMYALG LIYWEVFMRC 420
TDLFPGESVP DYQMAFQTEV GNHPTFEDMQ VLVSREKQRP KFPEAWKENS LAVRSLKETI 480
EDCWDQDAEA RLTAQCAEER MAELMMIWER NKSVSPTVNP MSTAMQNERN LSHNRRVPKI 540
GPYPDYSSSS YIEDSIHHTD SIVKNISSEH SMSSTPLTIG EKNRNSINYE RQQAQARIPS 600
PETSVTSLST NTTTTNTTGL TPSTGMTTIS EMPYPDETHL HATNVAQSIG PTPVCLQLTE 660
EDLETNKLDP KEVDKNLKES SDENLMEHSL KQFSGPDPLS STSSSLLYPL IKLAVEVTGQ 720
QDFTQAANGQ ACLIPDVPPA QIYPLPKQQN LPKRPTSLPL NTKNSTKEPR LKFGNKHKSN 780
LKQVETGVAK MNTINAAEPH VVTVTMNGVA GRSHNVNSHA ATTQYANGAV PAGQAANIVA 840
HRSQEMLQNQ FIGEDTRLNI NSSPDEHEPL LRREQQAGHD EGVLDRLVDR RERPLEGGRT 900
NSNNNNSNPC SEQDILTQGV TSTAADPGPS KPRRAQRPNS LDLSATNILD GSSIQIGEST 960
QDGKSGSGEK IKRRVKTPYS LKRWRPSTWV ISTEPLDCEV NNNGSDRAVH SKSSTAVYLA 1020
EGGTATTTVS KDIGMNCL 1038 
Gene Ontology
 GO:0005901; C:caveola; IEA:Compara.
 GO:0009986; C:cell surface; IDA:MGI.
 GO:0005887; C:integral to plasma membrane; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0005024; F:transforming growth factor beta-activated receptor activity; IEA:InterPro.
 GO:0009952; P:anterior/posterior pattern specification; IMP:MGI.
 GO:0060840; P:artery development; IMP:BHF-UCL.
 GO:0001974; P:blood vessel remodeling; IMP:BHF-UCL.
 GO:0030509; P:BMP signaling pathway; IMP:MGI.
 GO:0009267; P:cellular response to starvation; IEA:Compara.
 GO:0048286; P:lung alveolus development; IMP:BHF-UCL.
 GO:0001946; P:lymphangiogenesis; IMP:BHF-UCL.
 GO:0060836; P:lymphatic endothelial cell differentiation; IMP:BHF-UCL.
 GO:0001707; P:mesoderm formation; IMP:MGI.
 GO:0030308; P:negative regulation of cell growth; IEA:Compara.
 GO:2000279; P:negative regulation of DNA biosynthetic process; IEA:Compara.
 GO:0003085; P:negative regulation of systemic arterial blood pressure; IEA:Compara.
 GO:0045906; P:negative regulation of vasoconstriction; IMP:BHF-UCL.
 GO:0030513; P:positive regulation of BMP signaling pathway; IEA:Compara.
 GO:0030501; P:positive regulation of bone mineralization; IEA:Compara.
 GO:0010595; P:positive regulation of endothelial cell migration; IEA:Compara.
 GO:0001938; P:positive regulation of endothelial cell proliferation; IEA:Compara.
 GO:0045669; P:positive regulation of osteoblast differentiation; IEA:Compara.
 GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; IEA:Compara.
 GO:0001934; P:positive regulation of protein phosphorylation; ISO:MGI.
 GO:0014916; P:regulation of lung blood pressure; IMP:BHF-UCL.
 GO:0061298; P:retina vasculature development in camera-type eye; IMP:BHF-UCL.
 GO:0006366; P:transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0048010; P:vascular endothelial growth factor receptor signaling pathway; IMP:BHF-UCL.
 GO:0060841; P:venous blood vessel development; IMP:BHF-UCL. 
Interpro
 IPR000472; Activin_rcpt.
 IPR015770; BMPRII.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS. 
Pfam
 PF01064; Activin_recp
 PF00069; Pkinase 
SMART
  
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS