| Tag | Content |
|---|
| CPLM ID | CPLM-008891 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ephrin type-B receptor 4 |
Protein Synonyms/Alias | Hepatoma transmembrane kinase; Tyrosine-protein kinase TYRO11 |
Gene Name | EPHB4 |
Gene Synonyms/Alias | HTK; MYK1; TYRO11 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 973 | QHMKSQAKPGTPGGT | ubiquitination | [1] |
|
Reference | [1] Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Mol Cell. 2011 Oct 21;44(2):325-40. [ PMID: 21906983] |
Functional Description | Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4- mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis. |
Sequence Annotation | DOMAIN 17 202 Eph LBD.
DOMAIN 323 428 Fibronectin type-III 1.
DOMAIN 434 526 Fibronectin type-III 2.
DOMAIN 615 899 Protein kinase.
DOMAIN 907 971 SAM.
NP_BIND 621 629 ATP (By similarity).
MOTIF 985 987 PDZ-binding (Potential).
ACT_SITE 740 740 Proton acceptor (By similarity).
BINDING 647 647 ATP (By similarity).
MOD_RES 911 911 Phosphoserine.
MOD_RES 976 976 Phosphothreonine.
MOD_RES 987 987 Phosphotyrosine.
CARBOHYD 203 203 N-linked (GlcNAc...) (Potential).
CARBOHYD 335 335 N-linked (GlcNAc...) (Potential).
CARBOHYD 426 426 N-linked (GlcNAc...) (Potential).
DISULFID 61 184
DISULFID 97 107 |
Keyword | 3D-structure; Angiogenesis; ATP-binding; Cell membrane; Complete proteome; Developmental protein; Disulfide bond; Glycoprotein; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Repeat; Signal; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 987 AA |
Protein Sequence | MELRVLLCWA SLAAALEETL LNTKLETADL KWVTFPQVDG QWEELSGLDE EQHSVRTYEV 60
CDVQRAPGQA HWLRTGWVPR RGAVHVYATL RFTMLECLSL PRAGRSCKET FTVFYYESDA 120
DTATALTPAW MENPYIKVDT VAAEHLTRKR PGAEATGKVN VKTLRLGPLS KAGFYLAFQD 180
QGACMALLSL HLFYKKCAQL TVNLTRFPET VPRELVVPVA GSCVVDAVPA PGPSPSLYCR 240
EDGQWAEQPV TGCSCAPGFE AAEGNTKCRA CAQGTFKPLS GEGSCQPCPA NSHSNTIGSA 300
VCQCRVGYFR ARTDPRGAPC TTPPSAPRSV VSRLNGSSLH LEWSAPLESG GREDLTYALR 360
CRECRPGGSC APCGGDLTFD PGPRDLVEPW VVVRGLRPDF TYTFEVTALN GVSSLATGPV 420
PFEPVNVTTD REVPPAVSDI RVTRSSPSSL SLAWAVPRAP SGAVLDYEVK YHEKGAEGPS 480
SVRFLKTSEN RAELRGLKRG ASYLVQVRAR SEAGYGPFGQ EHHSQTQLDE SEGWREQLAL 540
IAGTAVVGVV LVLVVIVVAV LCLRKQSNGR EAEYSDKHGQ YLIGHGTKVY IDPFTYEDPN 600
EAVREFAKEI DVSYVKIEEV IGAGEFGEVC RGRLKAPGKK ESCVAIKTLK GGYTERQRRE 660
FLSEASIMGQ FEHPNIIRLE GVVTNSMPVM ILTEFMENGA LDSFLRLNDG QFTVIQLVGM 720
LRGIASGMRY LAEMSYVHRD LAARNILVNS NLVCKVSDFG LSRFLEENSS DPTYTSSLGG 780
KIPIRWTAPE AIAFRKFTSA SDAWSYGIVM WEVMSFGERP YWDMSNQDVI NAIEQDYRLP 840
PPPDCPTSLH QLMLDCWQKD RNARPRFPQV VSALDKMIRN PASLKIVARE NGGASHPLLD 900
QRQPHYSAFG SVGEWLRAIK MGRYEESFAA AGFGSFELVS QISAEDLLRI GVTLAGHQKK 960
ILASVQHMKS QAKPGTPGGT GGPAPQY 987 |
Gene Ontology | GO:0009986; C:cell surface; IDA:UniProtKB. GO:0005887; C:integral to plasma membrane; IDA:UniProtKB. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0005003; F:ephrin receptor activity; IDA:UniProtKB. GO:0007155; P:cell adhesion; IDA:UniProtKB. GO:0002042; P:cell migration involved in sprouting angiogenesis; IDA:UniProtKB. GO:0003007; P:heart morphogenesis; ISS:UniProtKB. GO:0046777; P:protein autophosphorylation; IDA:UniProtKB. |
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