CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019081
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Transcriptional adapter 1 
Protein Synonyms/Alias
 SPT3-associated factor 42; STAF42; Transcriptional adapter 1-like protein 
Gene Name
 TADA1 
Gene Synonyms/Alias
 TADA1L 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
12VSELEAAKKNLSEALubiquitination[1, 2]
13SELEAAKKNLSEALGubiquitination[1, 2]
35ANLKLWFKQKISKEEubiquitination[1]
40WFKQKISKEEFDLEAubiquitination[3]
128GAQQFVAKDPQDDDDubiquitination[1, 3]
205RLRDGHFKYAFGSNVubiquitination[1]
320HEELQQDKVHRQRLAubiquitination[1]
329HRQRLAAKEGLLLC*ubiquitination[1, 2, 4]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 
Functional Description
 Probably involved in transcriptional regulation. 
Sequence Annotation
  
Keyword
 Complete proteome; Nucleus; Polymorphism; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 335 AA 
Protein Sequence
MATFVSELEA AKKNLSEALG DNVKQYWANL KLWFKQKISK EEFDLEAHRL LTQDNVHSHN 60
DFLLAILTRC QILVSTPDGA GSLPWPGGSA AKPGKPKGKK KLSSVRQKFD HRFQPQNPLS 120
GAQQFVAKDP QDDDDLKLCS HTMMLPTRGQ LEGRMIVTAY EHGLDNVTEE AVSAVVYAVE 180
NHLKDILTSV VSRRKAYRLR DGHFKYAFGS NVTPQPYLKN SVVAYNNLIE SPPAFTAPCA 240
GQNPASHPPP DDAEQQAALL LACSGDTLPA SLPPVNMYDL FEALQVHREV IPTHTVYALN 300
IERIITKLWH PNHEELQQDK VHRQRLAAKE GLLLC 335 
Gene Ontology
 GO:0030914; C:STAGA complex; IDA:UniProtKB.
 GO:0003713; F:transcription coactivator activity; IDA:UniProtKB.
 GO:0043966; P:histone H3 acetylation; IDA:UniProtKB.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR024738; Hfi1/Tada1. 
Pfam
 PF12767; SAGA-Tad1 
SMART
  
PROSITE
  
PRINTS