UniProt Accession

 HEMO_RAT; P20059; Q5BKB4 

Genbank Protein ID

 M62642; X60006; BC091137 

Genbank Nucleotide ID

 AAA41337.1; CAA42621.1; AAH91137.1 

Protein Name

 Hemopexin 

Protein Synonyms/Alias

  

Gene Name

 Hpx 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
111	PDSVFLIKEDKVWVY	acetylation	[1]
341	NLVSGYPKRLEKELG	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. 

Sequence Annotation

 REPEAT 53 93 Hemopexin 1.
 REPEAT 94 138 Hemopexin 2.
 REPEAT 139 183 Hemopexin 3.
 REPEAT 184 230 Hemopexin 4.
 REPEAT 257 302 Hemopexin 5.
 REPEAT 303 350 Hemopexin 6.
 REPEAT 355 394 Hemopexin 7.
 REPEAT 398 448 Hemopexin 8.
 METAL 79 79 Iron (heme 1 axial ligand) (By
 METAL 149 149 Iron (heme 1 axial ligand) (By
 METAL 235 235 Iron (heme 2 axial ligand) (By
 METAL 291 291 Iron (heme 2 axial ligand) (By
 CARBOHYD 38 38 N-linked (GlcNAc...) (Potential).
 CARBOHYD 64 64 N-linked (GlcNAc...) (Potential).
 CARBOHYD 186 186 N-linked (GlcNAc...) (Potential).
 CARBOHYD 240 240 N-linked (GlcNAc...) (Potential).
 CARBOHYD 246 246 N-linked (GlcNAc...) (Potential).
 DISULFID 50 230 By similarity.
 DISULFID 148 153 By similarity.
 DISULFID 187 199 By similarity.
 DISULFID 255 458 By similarity.
 DISULFID 364 406 By similarity.
 DISULFID 416 433 By similarity.  

Keyword

 Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Heme; Iron; Metal-binding; Reference proteome; Repeat; Secreted; Signal; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 460 AA 

Protein Sequence

Gene Ontology

 GO:0005615; C:extracellular space; IEA:Compara.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0042168; P:heme metabolic process; IEA:Compara.
 GO:0020027; P:hemoglobin metabolic process; IEA:Compara.
 GO:0002925; P:positive regulation of humoral immune response mediated by circulating immunoglobulin; IEA:Compara.
 GO:0002639; P:positive regulation of immunoglobulin production; IEA:Compara.
 GO:0060335; P:positive regulation of interferon-gamma-mediated signaling pathway; IEA:Compara.
 GO:0042511; P:positive regulation of tyrosine phosphorylation of Stat1 protein; IEA:Compara.
 GO:0006810; P:transport; IEA:UniProtKB-KW. 

Interpro

 IPR000585; Hemopexin-like_dom.
 IPR018487; Hemopexin-like_repeat.
 IPR016358; Hemopexin_chordata.
 IPR018486; Hemopexin_CS. 

Pfam

 PF00045; Hemopexin 

SMART

 SM00120; HX 

PROSITE

 PS00024; HEMOPEXIN
 PS51642; HEMOPEXIN_2 

PRINTS