UniProt Accession

 BET1_HUMAN; O15155 

Genbank Protein ID

 AF007551; AC006378; BC000899 

Genbank Nucleotide ID

 AAB62941.1; AAD47132.1; AAH00899.1 

Protein Name

 BET1 homolog 

Protein Synonyms/Alias

 hBET1; Golgi vesicular membrane-trafficking protein p18 

Gene Name

 BET1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
47	RSKVTAIKSLSIEIG	ubiquitination	[1]
58	IEIGHEVKTQNKLLA	ubiquitination	[1]
62	HEVKTQNKLLAEMDS	ubiquitination	[1, 2, 3, 4]
80	STTGFLGKTMGKLKI	ubiquitination	[3]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572] 

Functional Description

 Required for vesicular transport from the ER to the Golgi complex. Functions as a SNARE involved in the docking process of ER-derived vesicles with the cis-Golgi membrane (By similarity). 

Sequence Annotation

 DOMAIN 26 88 t-SNARE coiled-coil homology.
 MOD_RES 50 50 Phosphoserine.  

Keyword

 3D-structure; Coiled coil; Complete proteome; Endoplasmic reticulum; ER-Golgi transport; Golgi apparatus; Membrane; Phosphoprotein; Protein transport; Reference proteome; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 118 AA 

Protein Sequence

Gene Ontology

 GO:0005801; C:cis-Golgi network; IEA:Compara.
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0031985; C:Golgi cisterna; IEA:Compara.
 GO:0000139; C:Golgi membrane; TAS:ProtInc.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0006888; P:ER to Golgi vesicle-mediated transport; TAS:ProtInc.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0048280; P:vesicle fusion with Golgi apparatus; IEA:Compara. 

Interpro

 IPR000727; T_SNARE_dom. 

Pfam

 PF05739; SNARE 

SMART

 SM00397; t_SNARE 

PROSITE

 PS50192; T_SNARE 

PRINTS