| Tag | Content |
|---|
| CPLM ID | CPLM-014931 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Elongator complex protein 2 |
Protein Synonyms/Alias | ELP2; SHINC-2; STAT3-interacting protein 1; StIP1 |
Gene Name | ELP2 |
Gene Synonyms/Alias | STATIP1 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 163 | VERGRAWKPPASLAL | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Regulates the ligand-dependent activation of STAT3 (By similarity). |
Sequence Annotation | REPEAT 13 53 WD 1.
REPEAT 56 100 WD 2.
REPEAT 105 152 WD 3.
REPEAT 158 200 WD 4.
REPEAT 205 246 WD 5.
REPEAT 281 329 WD 6.
REPEAT 339 378 WD 7.
REPEAT 386 425 WD 8.
REPEAT 436 474 WD 9.
REPEAT 565 609 WD 10.
REPEAT 612 651 WD 11.
REPEAT 667 706 WD 12.
REPEAT 712 753 WD 13.
REPEAT 777 826 WD 14. |
Keyword | Alternative splicing; Complete proteome; Cytoplasm; Nucleus; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation; WD repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 826 AA |
Protein Sequence | MVAPVLETSH VFCCPNRVRG VLNWSSGPRG LLAFGTSCSV VLYDPLKRVV VTNLNGHTAR 60
VNCIQWICKQ DGSPSTELVS GGSDNQVIHW EIEDNQLLKA VHLQGHEGPV YAVHAVYQRR 120
TSDPALCTLI VSAAADSAVR LWSKKGPEVT WKTGQVERGR AWKPPASLAL CSRSCDSMVS 180
CYASILCKAL WKEKLHTFWH HNRISFLPSA FRPIPILACG NDDCRIHIFA QQNDQFQKVL 240
SLCGHEDWIR GVEWAAFGRD LFLASCSQDC LIRIWKLYIK STSLETQDDD NIRLKENTFT 300
IENESVKIAF AVTLETVLAG HENWVNAVHW QPVFYKDGVL QQPVRLLSAS MDKTMILWAP 360
DEESGVWLEQ REWTPEIVIS GHFDGVQDLV WDPEGEFIIT VGTDQTTRLF APWKRKDQSQ 420
VTWHEIARPQ IHGYDLKCLA MINRFQFVSG ADEKVLRVFS APRNFVENFC AITGQSLNHV 480
LCNQDSDLPE GATVPALGLS NKAVFQGDIA SQPSDEEELL TSTGFEYQQV AFQPSILTEP 540
PTEDHLLQNT LWPEVQKLYG HGYEIFCVTC NSSKTLLASA CKAAKKEHAA IILWNTTSWK 600
QVQNLVFHSL TVTQMAFSPN EKFLLAVSRD RTWSLWKKQD TISPEFEPVF SLFAFTNKIT 660
SVHSRIIWSC DWSPDSKYFF TGSRDKKVVV WGECDSTDDC IEHNIGPCSS VLDVGGAVTA 720
VSVCPVLHPS QRYVVAVGLE CGKICLYTWK KTDQVPEIND WTHCVETSQS QSHTLAIRKL 780
CWKNCSGKTE QKEAEGAEWL HFASCGEDHT VKIHRVNKCA L 821 |
Gene Ontology | GO:0005737; C:cytoplasm; NAS:HGNC. GO:0016591; C:DNA-directed RNA polymerase II, holoenzyme; IC:HGNC. GO:0033588; C:Elongator holoenzyme complex; IDA:UniProtKB. GO:0005730; C:nucleolus; IC:HGNC. GO:0008023; C:transcription elongation factor complex; IDA:HGNC. GO:0046425; P:regulation of JAK-STAT cascade; IEA:Compara. GO:0006357; P:regulation of transcription from RNA polymerase II promoter; TAS:HGNC. GO:0006368; P:transcription elongation from RNA polymerase II promoter; IC:HGNC. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |