CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018953
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 General transcription factor IIH subunit 1 
Protein Synonyms/Alias
 TFIIH basal transcription factor complex subunit 1 
Gene Name
 Tfb1 
Gene Synonyms/Alias
 CG8151 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
270GDPLLDLKKFEDVPLacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II (By similarity). 
Sequence Annotation
 DOMAIN 104 159 BSD 1.
 DOMAIN 180 232 BSD 2.  
Keyword
 Complete proteome; DNA damage; DNA repair; Nucleus; Reference proteome; Repeat; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 585 AA 
Protein Sequence
MTTSSEDVLL QMGEVRYKKG DGTLYVMNER VAWMAEHRDT VTVSHRYADI KTQKISPEGK 60
PKVQLQVVLH DGNTSTFHFV NRQGQAAMLA DRDKVKELLQ QLLPNFKRKV DKDLEDKNRI 120
LVENPNLLQL YKDLVITKVL TSDEFWATHA KDHALKKMGR SQEIGVSGAF LADIKPQTDG 180
CNGLKYNLTS DVIHCIFKTY PAVKRKHFEN VPAKMSEAEF WTKFFQSHYF HRDRLTAGTK 240
DIFTECGKID DQALKAAVQQ GAGDPLLDLK KFEDVPLEEG FGSVAGDRNV VNSGNIVHQN 300
MIKRFNQHSI MVLKTCANVT SAPSTMTNGT NNANGPVSQS AYTNGMNGKG QATATATKSS 360
SDQVDKDEPQ SKKQRLMEKI HYVDLGDPIL EGDDSANGEK AKSKHFELSK VERYLNGPVQ 420
NSMYDNHNDP MSLEEVQYKL VRNSESWLNR NVQRTFICSK AAVNALGELS PGGSMMRGFQ 480
EQSAGQLVPN DFQRELRHLY LSLSELLKHF WSCFPPTSEE LETKLQRMHE TLQRFKMAKL 540
VPFENRAMHE LSPLRSSLTQ HLNQLLRTAN SKFATWKERK LRNTR 585 
Gene Ontology
 GO:0000439; C:core TFIIH complex; ISS:FlyBase.
 GO:0005675; C:holo TFIIH complex; IDA:FlyBase.
 GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0009411; P:response to UV; IMP:FlyBase.
 GO:0006367; P:transcription initiation from RNA polymerase II promoter; ISS:FlyBase. 
Interpro
 IPR005607; BSD.
 IPR011993; PH_like_dom.
 IPR027079; Tfb1/p62.
 IPR013876; TFIIH_BTF_p62_N. 
Pfam
 PF03909; BSD
 PF08567; TFIIH_BTF_p62_N 
SMART
 SM00751; BSD 
PROSITE
 PS50858; BSD 
PRINTS