UniProt Accession

 TF2H5_HUMAN; Q6ZYL4; Q0P5V8 

Genbank Protein ID

 AJ634743; AL590703; BC056906; BC060317 

Genbank Nucleotide ID

 CAG25512.1; CAH70241.1; AAH56906.1; AAH60317.1 

Protein Name

 General transcription factor IIH subunit 5 

Protein Synonyms/Alias

 General transcription factor IIH polypeptide 5; TFB5 ortholog; TFIIH basal transcription factor complex TTD-A subunit 

Gene Name

 GTF2H5 

Gene Synonyms/Alias

 C6orf175; TTDA 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
6	**MVNVLKGVLIECD	ubiquitination	[1]
31	DESNALGKKFIIQDI	ubiquitination	[2, 3, 4]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Component of the TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. Necessary for the stability of the TFIIH complex and for the presence of normal levels of TFIIH in the cell. 

Sequence Annotation

 MOD_RES 69 69 Phosphothreonine.  

Keyword

 3D-structure; Complete proteome; Disease mutation; DNA damage; DNA repair; Ichthyosis; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 71 AA 

Protein Sequence

Gene Ontology

 GO:0000439; C:core TFIIH complex; IEA:InterPro.
 GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR009400; TFIIH_TTDA/Tfb5. 

Pfam

 PF06331; Tbf5 

SMART

  

PROSITE

  

PRINTS