| Tag | Content |
|---|
| CPLM ID | CPLM-001983 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Troponin C, skeletal muscle |
Protein Synonyms/Alias | |
Gene Name | TNNC2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 38 | GGGDISVKELGTVMR | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments. |
Sequence Annotation | DOMAIN 15 50 EF-hand 1.
DOMAIN 51 86 EF-hand 2.
DOMAIN 91 126 EF-hand 3.
DOMAIN 127 160 EF-hand 4.
MOD_RES 2 2 N-acetylthreonine. |
Keyword | Acetylation; Calcium; Complete proteome; Direct protein sequencing; Metal-binding; Muscle protein; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 160 AA |
Protein Sequence | MTDQQAEARS YLSEEMIAEF KAAFDMFDAD GGGDISVKEL GTVMRMLGQT PTKEELDAII 60
EEVDEDGSGT IDFEEFLVMM VRQMKEDAKG KSEEELAECF RIFDRNADGY IDPEELAEIF 120
RASGEHVTDE EIESLMKDGD KNNDGRIDFD EFLKMMEGVQ 160 |
Gene Ontology | GO:0005829; C:cytosol; TAS:Reactome. GO:0005861; C:troponin complex; IDA:UniProtKB. GO:0005509; F:calcium ion binding; IEA:InterPro. GO:0030049; P:muscle filament sliding; TAS:Reactome. GO:0006937; P:regulation of muscle contraction; TAS:ProtInc. GO:0003009; P:skeletal muscle contraction; IDA:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |