UniProt Accession

 RIHC_ECOLI; P22564 

Genbank Protein ID

 X54945; U00096; AP009048 

Genbank Nucleotide ID

 CAA38708.1; AAC73141.1; BAB96599.1 

Protein Name

 Non-specific ribonucleoside hydrolase RihC 

Protein Synonyms/Alias

 Purine/pyrimidine ribonucleoside hydrolase 

Gene Name

 rihC 

Gene Synonyms/Alias

 yaaF; b0030; JW0028 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
97	DFVEHNRKPLGIPAF	acetylation	[1]
212	PQLNRTGKMLHALFS	acetylation	[2]

Reference

 [1] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111]
 [2] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Hydrolyzes both purine and pyrimidine ribonucleosides with a broad-substrate specificity with decreasing activity in the order uridine, xanthosine, inosine, adenosine, cytidine, guanosine. 

Sequence Annotation

 ACT_SITE 233 233 By similarity.  

Keyword

 Complete proteome; Glycosidase; Hydrolase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 304 AA 

Protein Sequence

Gene Ontology

 GO:0047622; F:adenosine nucleosidase activity; IDA:EcoCyc.
 GO:0047724; F:inosine nucleosidase activity; IDA:EcoCyc.
 GO:0045437; F:uridine nucleosidase activity; IDA:EcoCyc.
 GO:0006144; P:purine nucleobase metabolic process; IEA:HAMAP.
 GO:0006206; P:pyrimidine nucleobase metabolic process; IEA:HAMAP.
 GO:0006974; P:response to DNA damage stimulus; IEP:EcoliWiki.
 GO:0042454; P:ribonucleoside catabolic process; IDA:EcoCyc. 

Interpro

 IPR015910; I/U_nuclsd_hydro_CS.
 IPR023186; Inosine/uridine_hydrolase.
 IPR001910; Inosine/uridine_hydrolase_dom.
 IPR022976; Nucleosid_hydro_RihC_nonspecif. 

Pfam

 PF01156; IU_nuc_hydro 

SMART

  

PROSITE

 PS01247; IUNH 

PRINTS