CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032071
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nucleolar protein 11 
Protein Synonyms/Alias
 cDNA FLJ55361, highly similar to Nucleolar protein 11 
Gene Name
 NOL11 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
23QDENSVIKSFTASVDubiquitination[1]
65EKNQSLVKSLLLKAVubiquitination[2, 3]
70LVKSLLLKAVVSGNAubiquitination[1]
162SLAGALGKLKHSQDPubiquitination[1]
164AGALGKLKHSQDPGTubiquitination[1]
225QLLSTIMKDSEKHIEubiquitination[1]
229TIMKDSEKHIEVEVRubiquitination[1, 4]
237HIEVEVRKFLALKQTubiquitination[1]
242VRKFLALKQTPDFHTubiquitination[1, 2, 3, 4, 5]
263TGLLERCKAEPSFYPubiquitination[1]
374GFNPEEDKCNNCDQEubiquitination[5]
401TSCPVVQKRAALLNAubiquitination[1]
494RLLINLYKLVKSQISubiquitination[6]
518VSFRELQKLNQEKNNubiquitination[1, 4]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [6] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 537 AA 
Protein Sequence
MFNSRILTKY TLLLGQDENS VIKSFTASVD RKFISLMSLS SDGCIYETLI PIRPADPEKN 60
QSLVKSLLLK AVVSGNARNG VALTALDQDH VAVLGSPLAA SKECLSVWNI KFQTLQTSKE 120
LPQGTSGQLW YYGEHLFMLH GKSLTVIPYK CEVSSLAGAL GKLKHSQDPG THVVSHFVNW 180
ETPQGCGLGF QNSEQSRRIL RRRKIEVSLQ PEVPPSKQLL STIMKDSEKH IEVEVRKFLA 240
LKQTPDFHTV IGDTVTGLLE RCKAEPSFYP RNCLMQLIQT HVLSYSLCPD LMEIALKKKD 300
VQLLQLCLQQ FPDIPESVTC ACLKIFLSIG DDSLQETDVN MESVFDYSIN SVHDEKMEEQ 360
TEILQNGFNP EEDKCNNCDQ ELNKKPQDET KESTSCPVVQ KRAALLNAIL HSAYSETFLL 420
PHLKDIPAQH ITLFLKYLYF LYLKCSENAT MTLPGIHPPT LNQIMDWICL LLDANFTVVV 480
MMPEAKRLLI NLYKLVKSQI SVYSELNKIE VSFRELQKLN QEKNNRGLYS IEVLELF 537 
Gene Ontology
 GO:0005634; C:nucleus; IEA:InterPro. 
Interpro
 IPR012584; NUC205. 
Pfam
 PF08168; NUC205 
SMART
  
PROSITE
  
PRINTS