UniProt Accession

 RCN1_HUMAN; Q15293; D3DR00 

Genbank Protein ID

 D42073; AL078612; CH471064; CH471064; BC010120 

Genbank Nucleotide ID

 BAA07670.1; EAW68227.1; EAW68228.1; AAH10120.1 

Protein Name

 Reticulocalbin-1 

Protein Synonyms/Alias

  

Gene Name

 RCN1 

Gene Synonyms/Alias

 RCN 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
70	FLGKEDSKTFDQLTP	ubiquitination	[1]
81	QLTPDESKERLGKIV	acetylation	[2]
86	ESKERLGKIVDRIDN	acetylation	[3]
86	ESKERLGKIVDRIDN	ubiquitination	[1]
105	FVTTEELKTWIKRVQ	ubiquitination	[1]
122	YIFDNVAKVWKDYDR	ubiquitination	[1]
141	KISWEEYKQATYGYY	ubiquitination	[1]
165	SSDHHTFKKMLPRDE	ubiquitination	[1]
176	PRDERRFKAADLNGD	ubiquitination	[1]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 

Functional Description

 May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment. 

Sequence Annotation

 DOMAIN 79 114 EF-hand 1.
 DOMAIN 115 150 EF-hand 2.
 DOMAIN 166 201 EF-hand 3.
 DOMAIN 203 238 EF-hand 4.
 DOMAIN 244 279 EF-hand 5.
 DOMAIN 280 315 EF-hand 6.
 MOTIF 328 331 Prevents secretion from ER.
 MOD_RES 76 76 Phosphothreonine.
 CARBOHYD 53 53 N-linked (GlcNAc...).  

Keyword

 Calcium; Complete proteome; Endoplasmic reticulum; Glycoprotein; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 331 AA 

Protein Sequence

Gene Ontology

 GO:0005788; C:endoplasmic reticulum lumen; TAS:ProtInc.
 GO:0005509; F:calcium ion binding; TAS:ProtInc.
 GO:0043010; P:camera-type eye development; IEA:Compara.
 GO:0001701; P:in utero embryonic development; IEA:Compara. 

Interpro

 IPR011992; EF-hand-like_dom.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR002048; EF_hand_dom. 

Pfam

 PF13405; EF_hand_4
 PF13499; EF_hand_5 

SMART

 SM00054; EFh 

PROSITE

 PS00018; EF_HAND_1
 PS50222; EF_HAND_2
 PS00014; ER_TARGET 

PRINTS