UniProt Accession

 KDSR_HUMAN; Q06136; B2R5Y1 

Genbank Protein ID

 X63657; BT006782; AK312360; CH471096; BC008797 

Genbank Nucleotide ID

 CAA45197.1; AAP35428.1; BAG35278.1; EAW63140.1; AAH08797.1 

Protein Name

 3-ketodihydrosphingosine reductase 

Protein Synonyms/Alias

 KDS reductase; 3-dehydrosphinganine reductase; Follicular variant translocation protein 1; FVT-1 

Gene Name

 KDSR 

Gene Synonyms/Alias

 FVT1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
74	DKLLQAKKEIEMHSI	ubiquitination	[1]
246	SETTSVCKPEQVAKQ	ubiquitination	[1, 2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

 Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS). 

Sequence Annotation

 NP_BIND 36 60 NADP (Probable).
 ACT_SITE 186 186 Proton acceptor (By similarity).
 ACT_SITE 190 190 Probable.
 BINDING 173 173 Substrate (By similarity).  

Keyword

 Chromosomal rearrangement; Complete proteome; Endoplasmic reticulum; Lipid metabolism; Membrane; NADP; Oxidoreductase; Proto-oncogene; Reference proteome; Signal; Sphingolipid metabolism; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 332 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
 GO:0005615; C:extracellular space; TAS:ProtInc.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0047560; F:3-dehydrosphinganine reductase activity; IDA:MGI.
 GO:0006666; P:3-keto-sphinganine metabolic process; IDA:MGI.
 GO:0030148; P:sphingolipid biosynthetic process; TAS:Reactome. 

Interpro

 IPR002198; DH_sc/Rdtase_SDR.
 IPR002347; Glc/ribitol_DH.
 IPR016040; NAD(P)-bd_dom.
 IPR020904; Sc_DH/Rdtase_CS. 

Pfam

 PF00106; adh_short 

SMART

  

PROSITE

 PS00061; ADH_SHORT 

PRINTS

 PR00081; GDHRDH.
 PR00080; SDRFAMILY.