UniProt Accession

 HMW3_MYCPN; Q50360 

Genbank Protein ID

 L38997; U00089 

Genbank Nucleotide ID

 AAA61692.1; AAB96037.1 

Protein Name

 Cytadherence high molecular weight protein 3 

Protein Synonyms/Alias

 Accessory adhesin protein 3; Cytadherence accessory protein 3 

Gene Name

 hmw3 

Gene Synonyms/Alias

 MPN_452; MP389 

Created Date

 July 27, 2013 

Organism

 Mycoplasma pneumoniae (strain ATCC 29342 / M129) 

NCBI Taxa ID

 272634 

Lysine Modification

Position	Peptide	Type	References
4	****MTDKERAKLAK	acetylation	[1]
56	GNIFSLEKRKQLPAD	acetylation	[1]
345	VEATPAPKVEPKVVE	acetylation	[1]
416	AVVQPVVKAEPKVVT	acetylation	[1]
440	TPQVATPKVTPKVVQ	acetylation	[1]

Reference

 [1] Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium.
 van Noort V, Seebacher J, Bader S, Mohammed S, Vonkova I, Betts MJ, Kühner S, Kumar R, Maier T, O'Flaherty M, Rybin V, Schmeisky A, Yus E, Stülke J, Serrano L, Russell RB, Heck AJ, Bork P, Gavin AC.
 Mol Syst Biol. 2012 Feb 28;8:571. [PMID: 22373819] 

Functional Description

 Component of the cytoskeleton-like structure which stabilizes the shape of the wall-less mycoplasma. This cytoskeleton-like network of accessory proteins containing HMW proteins 1 to 5 allows the proper anchoring of cytadhesin proteins in the mycoplasmal membrane at the attachment organelle. Essential for successful surface parasitism. 

Sequence Annotation

 REPEAT 98 100 1-1.
 REPEAT 106 108 1-2.
 REPEAT 160 162 2-1.
 REPEAT 197 199 1-3.
 REPEAT 206 208 1-4.
 REPEAT 211 213 1-5.
 REPEAT 221 223 1-6.
 REPEAT 226 228 1-7.
 REPEAT 235 237 1-8.
 REPEAT 249 251 1-9.
 REPEAT 288 290 2-2.
 REPEAT 310 319 3-1.
 REPEAT 312 316 4-1.
 REPEAT 316 318 2-3.
 REPEAT 322 324 2-4.
 REPEAT 330 339 3-2.
 REPEAT 332 336 4-2.
 REPEAT 336 338 2-5.
 REPEAT 354 358 4-3.
 REPEAT 385 389 4-4.
 REPEAT 396 400 4-5.
 REPEAT 402 404 2-6.
 REPEAT 413 415 2-7.
 REPEAT 424 428 4-6.
 REPEAT 454 456 2-8.
 REGION 98 251 9 X 3 AA repeats OF Y-D-Q.
 REGION 160 456 8 X 3 AA repeats of P-V-V.
 REGION 310 339 2 X 10 AA repeats of V-E-P-T-P-T-P-V-V-E.
 REGION 312 428 6 X 5 AA repeats of P-X-P-X-P.  

Keyword

 Cell membrane; Cell projection; Complete proteome; Cytadherence; Direct protein sequencing; Membrane; Reference proteome; Repeat; Virulence. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 672 AA 

Protein Sequence

Gene Ontology

 GO:0033111; C:attachment organelle membrane; IEA:UniProtKB-SubCell.
 GO:0042995; C:cell projection; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
 GO:0020035; P:cytoadherence to microvasculature, mediated by symbiont protein; IEA:UniProtKB-KW.
 GO:0009405; P:pathogenesis; IEA:UniProtKB-KW. 

Interpro

  

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