CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-034355
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Disks large homolog 1 
Protein Synonyms/Alias
  
Gene Name
 Dlg1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
208VRDVTHSKAVEALKEubiquitination[1]
214SKAVEALKEAGSIVRubiquitination[1]
238SEKIMEIKLIKGPKGacetylation[2]
238SEKIMEIKLIKGPKGubiquitination[1]
369ARYSPISKAVLGDDEubiquitination[1]
511RALFDYDKTKDSGLPubiquitination[1]
561EVGVIPSKRRVEKKEubiquitination[1]
654VIILGPMKDRVNDDLubiquitination[1]
668LISEFPDKFGSCVPHacetylation[3]
668LISEFPDKFGSCVPHubiquitination[1]
773ENIMEMNKRLTEEQAubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; SH3 domain. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 834 AA 
Protein Sequence
MNYIFGNNTL LYSRASRGGN ASSSHGSVGP KQKHWAKKGS SDELQAEPEP SRWQQIVAFF 60
TRRHSFIDCI SVATSSTQPT EAVPPSSPIV PVTPALPVPA ESTVVLPSAP QANPPPVLVN 120
TDSLETPTYV NGTDADYEYE EITLERGNSG LGFSIAGGTD NPHIGDDSSI FITKIITGGA 180
AAQDGRLRVN DCILRVNEAD VRDVTHSKAV EALKEAGSIV RLYVKRRKPA SEKIMEIKLI 240
KGPKGLGFSI AGGVGNQHIP GDNSIYVTKI IEGGAAHKDG KLQIGDKLLA VNSVCLEEVT 300
HEEAVTALKN TSDFVYLKVA KPTSMYINDG YAPPDITNSS SQSVDNHVSP SSCLGQTPTS 360
PARYSPISKA VLGDDEITRE PRKVVLHRGS TGLGFNIVGG EDGEGIFISF ILAGGPADLS 420
GELRKGDRII SVNSVDLRAA SHEQAAAALK NAGQAVTIVA QYRPEEYSRF EAKIHDLREQ 480
MMNSSVSSGS GSLRTSQKRS LYVRALFDYD KTKDSGLPSQ GLNFRFGDIL HVINASDDEW 540
WQARQVTPDG ESDEVGVIPS KRRVEKKERA RLKTVKFNSK TRGDKGEIPD DMGSKGLKHV 600
TSNASDSESS YLILITDEYG CSKGGQEEYV LSYEPVNQQE VNYTRPVIIL GPMKDRVNDD 660
LISEFPDKFG SCVPHTTRPK RDYEVDGRDY HFVTSREQME KDIQEHKFIE AGQYNNHLYG 720
TSVQSVRAVA EKGKHCILDV SGNAIKRLQI AQLYPISIFI KPKSMENIME MNKRLTEEQA 780
RKTFERAMKL EQEFTEHFTA IVQGDTLEDI YNQVKQIIEE QSGPYIWVPA KEKL 834 
Gene Ontology
 GO:0016323; C:basolateral plasma membrane; IDA:MGI.
 GO:0030054; C:cell junction; IDA:MGI.
 GO:0031253; C:cell projection membrane; IDA:MGI.
 GO:0001772; C:immunological synapse; IDA:MGI.
 GO:0016328; C:lateral plasma membrane; IDA:MGI.
 GO:0045121; C:membrane raft; IDA:MGI.
 GO:0031594; C:neuromuscular junction; IDA:MGI.
 GO:0014069; C:postsynaptic density; IDA:MGI.
 GO:0032947; F:protein complex scaffold; IMP:MGI.
 GO:0032147; P:activation of protein kinase activity; IMP:MGI.
 GO:0042982; P:amyloid precursor protein metabolic process; IGI:MGI.
 GO:0001658; P:branching involved in ureteric bud morphogenesis; IMP:MGI.
 GO:0048704; P:embryonic skeletal system morphogenesis; IMP:MGI.
 GO:0060022; P:hard palate development; IMP:MGI.
 GO:0001771; P:immunological synapse formation; IMP:MGI.
 GO:0002088; P:lens development in camera-type eye; IMP:MGI.
 GO:0031579; P:membrane raft organization; IMP:MGI.
 GO:0050680; P:negative regulation of epithelial cell proliferation; IMP:MGI.
 GO:0042130; P:negative regulation of T cell proliferation; IMP:MGI.
 GO:0030432; P:peristalsis; IMP:MGI.
 GO:0030838; P:positive regulation of actin filament polymerization; IMP:MGI.
 GO:0008284; P:positive regulation of cell proliferation; IMP:MGI.
 GO:0008104; P:protein localization; IMP:MGI.
 GO:0042391; P:regulation of membrane potential; IGI:MGI.
 GO:0048608; P:reproductive structure development; IMP:MGI.
 GO:0048745; P:smooth muscle tissue development; IMP:MGI.
 GO:0042110; P:T cell activation; IMP:MGI.
 GO:0002369; P:T cell cytokine production; IMP:MGI. 
Interpro
 IPR008144; Guanylate_kin.
 IPR008145; Guanylate_kin/L-typ_Ca_channel.
 IPR020590; Guanylate_kinase_CS.
 IPR016313; M-assoc_guanylate_kinase.
 IPR019590; MAGUK_PEST_N.
 IPR027417; P-loop_NTPase.
 IPR001478; PDZ.
 IPR019583; PDZ_assoc.
 IPR011511; SH3_2.
 IPR001452; SH3_domain. 
Pfam
 PF00625; Guanylate_kin
 PF10608; MAGUK_N_PEST
 PF00595; PDZ
 PF10600; PDZ_assoc
 PF07653; SH3_2 
SMART
 SM00072; GuKc
 SM00228; PDZ
 SM00326; SH3 
PROSITE
 PS00856; GUANYLATE_KINASE_1
 PS50052; GUANYLATE_KINASE_2
 PS50106; PDZ
 PS50002; SH3 
PRINTS